PURO_HALS3
ID PURO_HALS3 Reviewed; 194 AA.
AC B0R7Q4;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 1.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=IMP cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00705};
DE EC=3.5.4.10 {ECO:0000255|HAMAP-Rule:MF_00705};
DE AltName: Full=IMP synthase {ECO:0000255|HAMAP-Rule:MF_00705};
DE AltName: Full=Inosinicase {ECO:0000255|HAMAP-Rule:MF_00705};
GN Name=purO {ECO:0000255|HAMAP-Rule:MF_00705}; OrderedLocusNames=OE_4329F;
OS Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium.
OX NCBI_TaxID=478009;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29341 / DSM 671 / R1;
RX PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT R1 compared to that of strain NRC-1.";
RL Genomics 91:335-346(2008).
CC -!- FUNCTION: Catalyzes the cyclization of 5-formylamidoimidazole-4-
CC carboxamide ribonucleotide to IMP. {ECO:0000255|HAMAP-Rule:MF_00705}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-
CC carboxamide; Xref=Rhea:RHEA:18445, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:58053, ChEBI:CHEBI:58467; EC=3.5.4.10;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00705};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; IMP
CC from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step
CC 1/1. {ECO:0000255|HAMAP-Rule:MF_00705}.
CC -!- SIMILARITY: Belongs to the archaeal IMP cyclohydrolase family.
CC {ECO:0000255|HAMAP-Rule:MF_00705}.
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DR EMBL; AM774415; CAP14773.1; -; Genomic_DNA.
DR RefSeq; WP_010903769.1; NC_010364.1.
DR AlphaFoldDB; B0R7Q4; -.
DR SMR; B0R7Q4; -.
DR EnsemblBacteria; CAP14773; CAP14773; OE_4329F.
DR GeneID; 5954394; -.
DR KEGG; hsl:OE_4329F; -.
DR HOGENOM; CLU_1352116_0_0_2; -.
DR OMA; HVDPIAE; -.
DR PhylomeDB; B0R7Q4; -.
DR UniPathway; UPA00074; UER00135.
DR Proteomes; UP000001321; Chromosome.
DR GO; GO:0003937; F:IMP cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.60.20.20; -; 1.
DR HAMAP; MF_00705; IMP_cyclohydrol; 1.
DR InterPro; IPR010191; IMP_cyclohydrolase.
DR InterPro; IPR020600; IMP_cyclohydrolase-like.
DR InterPro; IPR036795; IMP_cyclohydrolase-like_sf.
DR Pfam; PF07826; IMP_cyclohyd; 1.
DR PIRSF; PIRSF004866; IMP_cclhdr_arch; 1.
DR SUPFAM; SSF75569; SSF75569; 1.
DR TIGRFAMs; TIGR01922; purO_arch; 1.
PE 3: Inferred from homology;
KW Hydrolase; Purine biosynthesis.
FT CHAIN 1..194
FT /note="IMP cyclohydrolase"
FT /id="PRO_0000349158"
SQ SEQUENCE 194 AA; 20480 MW; EDFD07EC29BBB328 CRC64;
MYIGRFVVVG PSVAAYRVSS RSFPNRKLIE RPAGLTVVPT ADAEETTNPY VSYNCVRTAG
GHAVVGNGSH VDPITEKVER GYPPRDALTE ALLAMDYEKD DYDTPRIAGV LAPDGTAYVG
IVRADAVLVR AVEEPTLVAT YEKDAPEAIG FDAATAADAA REAYSAAFEH AVCAAGVSRR
GVGDGYDTAV VNDP