PURO_META3
ID PURO_META3 Reviewed; 203 AA.
AC A6UV34;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=IMP cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00705};
DE EC=3.5.4.10 {ECO:0000255|HAMAP-Rule:MF_00705};
DE AltName: Full=IMP synthase {ECO:0000255|HAMAP-Rule:MF_00705};
DE AltName: Full=Inosinicase {ECO:0000255|HAMAP-Rule:MF_00705};
GN Name=purO {ECO:0000255|HAMAP-Rule:MF_00705}; OrderedLocusNames=Maeo_0773;
OS Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 /
OS Nankai-3).
OC Archaea; Euryarchaeota; Methanomada group; Methanococci; Methanococcales;
OC Methanococcaceae; Methanococcus.
OX NCBI_TaxID=419665;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E.,
RA Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J.,
RA Larimer F., Land M., Hauser L., Kyrpides N., Lykidis A.,
RA Sieprawska-Lupa M., Whitman W.B., Richardson P.;
RT "Complete sequence of Methanococcus aeolicus Nankai-3.";
RL Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the cyclization of 5-formylamidoimidazole-4-
CC carboxamide ribonucleotide to IMP. {ECO:0000255|HAMAP-Rule:MF_00705}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-
CC carboxamide; Xref=Rhea:RHEA:18445, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:58053, ChEBI:CHEBI:58467; EC=3.5.4.10;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_00705};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; IMP
CC from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step
CC 1/1. {ECO:0000255|HAMAP-Rule:MF_00705}.
CC -!- SIMILARITY: Belongs to the archaeal IMP cyclohydrolase family.
CC {ECO:0000255|HAMAP-Rule:MF_00705}.
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DR EMBL; CP000743; ABR56356.1; -; Genomic_DNA.
DR RefSeq; WP_011973488.1; NC_009635.1.
DR AlphaFoldDB; A6UV34; -.
DR SMR; A6UV34; -.
DR STRING; 419665.Maeo_0773; -.
DR EnsemblBacteria; ABR56356; ABR56356; Maeo_0773.
DR GeneID; 5326256; -.
DR KEGG; mae:Maeo_0773; -.
DR eggNOG; arCOG04727; Archaea.
DR HOGENOM; CLU_1352116_0_0_2; -.
DR OMA; HVDPIAE; -.
DR OrthoDB; 106750at2157; -.
DR UniPathway; UPA00074; UER00135.
DR Proteomes; UP000001106; Chromosome.
DR GO; GO:0003937; F:IMP cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.60.20.20; -; 1.
DR HAMAP; MF_00705; IMP_cyclohydrol; 1.
DR InterPro; IPR010191; IMP_cyclohydrolase.
DR InterPro; IPR020600; IMP_cyclohydrolase-like.
DR InterPro; IPR036795; IMP_cyclohydrolase-like_sf.
DR Pfam; PF07826; IMP_cyclohyd; 1.
DR PIRSF; PIRSF004866; IMP_cclhdr_arch; 1.
DR SUPFAM; SSF75569; SSF75569; 1.
DR TIGRFAMs; TIGR01922; purO_arch; 1.
PE 3: Inferred from homology;
KW Hydrolase; Purine biosynthesis; Reference proteome.
FT CHAIN 1..203
FT /note="IMP cyclohydrolase"
FT /id="PRO_0000349161"
SQ SEQUENCE 203 AA; 22766 MW; 5D9FB69B19406C40 CRC64;
MYIGRFLVVG KTQQGKPFVS YRVSSRSFPN RKAVINNTND TVAILPNDLN DMFANPYIAY
NCIKIVGNTV IATNGTHTDI IADKIKLELP IRDALALSLI AMDYEKDDYN TPRIAVVLNE
NTAYMGYVAD NDIRIKEVPL KDGLAYYLST YECCRISTEH QNIVVDGENP EEICKFVMDY
EKFEKPVCCA TATIDGDIEL GTL