ID   PURO_METAR              Reviewed;         201 AA.
AC   Q0W6S4;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=IMP cyclohydrolase {ECO:0000255|HAMAP-Rule:MF_00705};
DE            EC=3.5.4.10 {ECO:0000255|HAMAP-Rule:MF_00705};
DE   AltName: Full=IMP synthase {ECO:0000255|HAMAP-Rule:MF_00705};
DE   AltName: Full=Inosinicase {ECO:0000255|HAMAP-Rule:MF_00705};
GN   Name=purO {ECO:0000255|HAMAP-Rule:MF_00705}; OrderedLocusNames=UNCMA_22650;
GN   ORFNames=RCIX491;
OS   Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanocellales; Methanocellaceae; Methanocella.
OX   NCBI_TaxID=351160;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 22066 / NBRC 105507 / MRE50;
RX   PubMed=16857943; DOI=10.1126/science.1127062;
RA   Erkel C., Kube M., Reinhardt R., Liesack W.;
RT   "Genome of rice cluster I archaea -- the key methane producers in the rice
RT   rhizosphere.";
RL   Science 313:370-372(2006).
CC   -!- FUNCTION: Catalyzes the cyclization of 5-formylamidoimidazole-4-
CC       carboxamide ribonucleotide to IMP. {ECO:0000255|HAMAP-Rule:MF_00705}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-
CC         carboxamide; Xref=Rhea:RHEA:18445, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:58053, ChEBI:CHEBI:58467; EC=3.5.4.10;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00705};
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; IMP
CC       from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step
CC       1/1. {ECO:0000255|HAMAP-Rule:MF_00705}.
CC   -!- SIMILARITY: Belongs to the archaeal IMP cyclohydrolase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00705}.
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DR   EMBL; AM114193; CAJ35919.1; -; Genomic_DNA.
DR   RefSeq; WP_012036585.1; NC_009464.1.
DR   AlphaFoldDB; Q0W6S4; -.
DR   SMR; Q0W6S4; -.
DR   STRING; 351160.RCIX491; -.
DR   EnsemblBacteria; CAJ35919; CAJ35919; RCIX491.
DR   GeneID; 5144770; -.
DR   KEGG; rci:RCIX491; -.
DR   PATRIC; fig|351160.9.peg.2318; -.
DR   eggNOG; arCOG04727; Archaea.
DR   OMA; HVDPIAE; -.
DR   OrthoDB; 106750at2157; -.
DR   UniPathway; UPA00074; UER00135.
DR   Proteomes; UP000000663; Chromosome.
DR   GO; GO:0003937; F:IMP cyclohydrolase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.60.20.20; -; 1.
DR   HAMAP; MF_00705; IMP_cyclohydrol; 1.
DR   InterPro; IPR010191; IMP_cyclohydrolase.
DR   InterPro; IPR020600; IMP_cyclohydrolase-like.
DR   InterPro; IPR036795; IMP_cyclohydrolase-like_sf.
DR   Pfam; PF07826; IMP_cyclohyd; 1.
DR   PIRSF; PIRSF004866; IMP_cclhdr_arch; 1.
DR   SUPFAM; SSF75569; SSF75569; 1.
DR   TIGRFAMs; TIGR01922; purO_arch; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Purine biosynthesis; Reference proteome.
FT   CHAIN           1..201
FT                   /note="IMP cyclohydrolase"
FT                   /id="PRO_0000349171"
SQ   SEQUENCE   201 AA;  22268 MW;  0DF11711F62264F7 CRC64;
     MYVGRFVTIG KTNGRLWAGY RVSSRSFPNR YAVKLGDDKV AIMPKDVKDL EKSPYISYNC
     IRVLPSVAVV TNGSHTDAIV EKIEMGYPIR DALALSLLAM DYEKDSLDTP RIAAVVSRHV
     AYLGIVTKDG LNVSTFPMGD NECLMVATYE KTMFSRLTVD ASSAEEVARK MYDLTFEKPV
     CAAGAYQVDD HFELGVYNGP Q