PURP_CHICK
ID PURP_CHICK Reviewed; 196 AA.
AC P08938;
DT 01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1988, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Purpurin;
DE Flags: Precursor;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3652208; DOI=10.1016/0092-8674(87)90018-3;
RA Berman P., Gray P., Chen E., Keyser K., Ehrlich D., Karten H.,
RA Lacorbiere M., Esch F., Schubert D.;
RT "Sequence analysis, cellular localization, and expression of a neuroretina
RT adhesion and cell survival molecule.";
RL Cell 51:135-142(1987).
RN [2]
RP PROTEIN SEQUENCE OF 66-84; 98-109; 122-127 AND 141-155.
RX PubMed=3754874; DOI=10.1083/jcb.102.6.2295;
RA Schubert D., Lacorbiere M., Esch F.;
RT "A chick neural retina adhesion and survival molecule is a retinol-binding
RT protein.";
RL J. Cell Biol. 102:2295-2301(1986).
CC -!- FUNCTION: May be involved in the transport of retinol between the
CC photoreceptors and the pigmented epithelium.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, interphotoreceptor matrix.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC {ECO:0000305}.
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DR EMBL; M17538; AAA49033.1; -; mRNA.
DR PIR; A26677; A26677.
DR PIR; A26969; A26969.
DR RefSeq; NP_990798.1; NM_205467.3.
DR AlphaFoldDB; P08938; -.
DR SMR; P08938; -.
DR STRING; 9031.ENSGALP00000024759; -.
DR PaxDb; P08938; -.
DR Ensembl; ENSGALT00000024805; ENSGALP00000024759; ENSGALG00000015374.
DR GeneID; 396454; -.
DR KEGG; gga:396454; -.
DR CTD; 5950; -.
DR VEuPathDB; HostDB:geneid_396454; -.
DR eggNOG; ENOG502QQ8B; Eukaryota.
DR GeneTree; ENSGT00510000047107; -.
DR HOGENOM; CLU_094618_0_0_1; -.
DR InParanoid; P08938; -.
DR OMA; TTPAKMY; -.
DR OrthoDB; 1631943at2759; -.
DR PhylomeDB; P08938; -.
DR TreeFam; TF331445; -.
DR PRO; PR:P08938; -.
DR Proteomes; UP000000539; Chromosome Z.
DR Bgee; ENSGALG00000015374; Expressed in liver and 11 other tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProt.
DR GO; GO:0033165; C:interphotoreceptor matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0016918; F:retinal binding; IEA:UniProtKB-KW.
DR GO; GO:0019841; F:retinol binding; IEA:UniProtKB-KW.
DR GO; GO:0034632; F:retinol transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR022271; Lipocalin_ApoD.
DR InterPro; IPR022272; Lipocalin_CS.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR InterPro; IPR002449; Retinol-bd/Purpurin.
DR PANTHER; PTHR11873; PTHR11873; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR PIRSF; PIRSF036893; Lipocalin_ApoD; 1.
DR PIRSF; PIRSF500204; RBP_purpurin; 1.
DR PRINTS; PR01174; RETINOLBNDNG.
DR SUPFAM; SSF50814; SSF50814; 1.
DR PROSITE; PS00213; LIPOCALIN; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Extracellular matrix;
KW Reference proteome; Retinol-binding; Secreted; Signal; Transport;
KW Vitamin A.
FT SIGNAL 1..21
FT CHAIN 22..196
FT /note="Purpurin"
FT /id="PRO_0000017957"
FT DISULFID 24..182
FT /evidence="ECO:0000250"
FT DISULFID 90..196
FT /evidence="ECO:0000250"
FT DISULFID 142..151
FT /evidence="ECO:0000250"
SQ SEQUENCE 196 AA; 21922 MW; 74E30A6F6599F4BF CRC64;
MKYAQYVFLA SIFSAVEYSL AQTCAVDSFS VKDNFDPKRY AGKWYALAKK DPEGLFLQDN
ISAEYTVEED GTMTASSKGR VKLFGFWVIC ADMAAQYTVP DPTTPAKMYM TYQGLASYLS
SGGDNYWVID TDYDNYAITY ACRSLKEDGS CDDGYSLIFS RNPRGLPPAI QRIVRQKQEE
ICMSGQFQPV LQSGAC
