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ATP6_PIG
ID   ATP6_PIG                Reviewed;         226 AA.
AC   Q35915; O79878;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=ATP synthase subunit a;
DE   AltName: Full=F-ATPase protein 6;
GN   Name=MT-ATP6; Synonyms=ATP6, ATPASE6, MTATP6;
OS   Sus scrofa (Pig).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9732457; DOI=10.1007/pl00006388;
RA   Ursing B.M., Arnason U.;
RT   "The complete mitochondrial DNA sequence of the pig (Sus scrofa).";
RL   J. Mol. Evol. 47:302-306(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Landrace;
RX   PubMed=10433971; DOI=10.1016/s0378-1119(99)00247-4;
RA   Lin C.S., Sun Y.L., Liu C.Y., Yang P.C., Chang L.C., Cheng I.C.,
RA   Mao S.J.T., Huang M.C.;
RT   "Complete nucleotide sequence of pig (Sus scrofa) mitochondrial genome and
RT   dating evolutionary divergence within artiodactyla.";
RL   Gene 236:107-114(1999).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-37.
RX   PubMed=3017295; DOI=10.1007/bf00499094;
RA   Watanabe T., Hayashi Y., Kimura J., Yasuda Y., Saitou N., Tomita T.,
RA   Ogasawara N.;
RT   "Pig mitochondrial DNA: polymorphism, restriction map orientation, and
RT   sequence data.";
RL   Biochem. Genet. 24:385-396(1986).
CC   -!- FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or
CC       Complex V) produces ATP from ADP in the presence of a proton gradient
CC       across the membrane which is generated by electron transport complexes
CC       of the respiratory chain. F-type ATPases consist of two structural
CC       domains, F(1) - containing the extramembraneous catalytic core and F(0)
CC       - containing the membrane proton channel, linked together by a central
CC       stalk and a peripheral stalk. During catalysis, ATP synthesis in the
CC       catalytic domain of F(1) is coupled via a rotary mechanism of the
CC       central stalk subunits to proton translocation. Key component of the
CC       proton channel; it may play a direct role in the translocation of
CC       protons across the membrane.
CC   -!- SUBUNIT: F-type ATPases have 2 components, CF(1) - the catalytic core
CC       - and CF(0) - the membrane proton channel. CF(1) has five subunits:
CC       alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main
CC       subunits: a, b and c. Component of an ATP synthase complex composed of
CC       ATP5PB, ATP5MC1, ATP5F1E, ATP5PD, ATP5ME, ATP5PF, ATP5MF, MT-ATP6, MT-
CC       ATP8, ATP5F1A, ATP5F1B, ATP5F1D, ATP5F1C, ATP5PO, ATP5MG, ATP5MK and
CC       ATP5MJ (By similarity). Interacts with DNAJC30; interaction is direct
CC       (By similarity). {ECO:0000250|UniProtKB:P00846,
CC       ECO:0000250|UniProtKB:P00847}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane
CC       protein.
CC   -!- SIMILARITY: Belongs to the ATPase A chain family. {ECO:0000305}.
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DR   EMBL; AJ002189; CAA05234.1; -; Genomic_DNA.
DR   EMBL; AF034253; AAD34190.1; -; Genomic_DNA.
DR   EMBL; M26139; AAA32031.1; -; Genomic_DNA.
DR   PIR; T10977; T10977.
DR   RefSeq; NP_008639.1; NC_000845.1.
DR   PDB; 6J54; EM; 3.94 A; a=1-226.
DR   PDB; 6J5A; EM; 4.35 A; a=1-226.
DR   PDB; 6J5I; EM; 3.34 A; a=1-226.
DR   PDB; 6J5J; EM; 3.45 A; a=1-226.
DR   PDB; 6J5K; EM; 6.20 A; Aa/Ba/Ca/a=1-226.
DR   PDB; 6ZMR; EM; 3.94 A; a=1-226.
DR   PDB; 6ZNA; EM; 6.20 A; Aa/Ba/Ca/a=1-226.
DR   PDBsum; 6J54; -.
DR   PDBsum; 6J5A; -.
DR   PDBsum; 6J5I; -.
DR   PDBsum; 6J5J; -.
DR   PDBsum; 6J5K; -.
DR   PDBsum; 6ZMR; -.
DR   PDBsum; 6ZNA; -.
DR   AlphaFoldDB; Q35915; -.
DR   SMR; Q35915; -.
DR   IntAct; Q35915; 2.
DR   STRING; 9823.ENSSSCP00000019140; -.
DR   PaxDb; Q35915; -.
DR   PeptideAtlas; Q35915; -.
DR   Ensembl; ENSSSCT00000019676; ENSSSCP00000019140; ENSSSCG00000018081.
DR   Ensembl; ENSSSCT00070061678; ENSSSCP00070052583; ENSSSCG00070030641.
DR   GeneID; 808506; -.
DR   KEGG; ssc:808506; -.
DR   CTD; 4508; -.
DR   VGNC; VGNC:108745; MT-ATP6.
DR   eggNOG; KOG4665; Eukaryota.
DR   GeneTree; ENSGT00390000005568; -.
DR   HOGENOM; CLU_041018_0_2_1; -.
DR   InParanoid; Q35915; -.
DR   OMA; FFDQFMS; -.
DR   OrthoDB; 1095315at2759; -.
DR   TreeFam; TF343395; -.
DR   Reactome; R-SSC-163210; Formation of ATP by chemiosmotic coupling.
DR   Reactome; R-SSC-8949613; Cristae formation.
DR   Proteomes; UP000008227; Mitochondrion.
DR   Proteomes; UP000314985; Mitochondrion.
DR   Bgee; ENSSSCG00000018081; Expressed in prefrontal cortex and 44 other tissues.
DR   ExpressionAtlas; Q35915; baseline and differential.
DR   Genevisible; Q35915; SS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005753; C:mitochondrial proton-transporting ATP synthase complex; ISS:UniProtKB.
DR   GO; GO:0045263; C:proton-transporting ATP synthase complex, coupling factor F(o); IEA:UniProtKB-KW.
DR   GO; GO:0015078; F:proton transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015986; P:proton motive force-driven ATP synthesis; IBA:GO_Central.
DR   Gene3D; 1.20.120.220; -; 1.
DR   InterPro; IPR000568; ATP_synth_F0_asu.
DR   InterPro; IPR023011; ATP_synth_F0_asu_AS.
DR   InterPro; IPR045083; ATP_synth_F0_asu_bact/mt.
DR   InterPro; IPR035908; F0_ATP_A_sf.
DR   PANTHER; PTHR11410; PTHR11410; 1.
DR   Pfam; PF00119; ATP-synt_A; 1.
DR   PRINTS; PR00123; ATPASEA.
DR   SUPFAM; SSF81336; SSF81336; 1.
DR   TIGRFAMs; TIGR01131; ATP_synt_6_or_A; 1.
DR   PROSITE; PS00449; ATPASE_A; 1.
PE   1: Evidence at protein level;
KW   3D-structure; ATP synthesis; CF(0); Hydrogen ion transport; Ion transport;
KW   Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..226
FT                   /note="ATP synthase subunit a"
FT                   /id="PRO_0000082154"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        164..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        189..209
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        30..37
FT                   /note="LFPTPKRL -> SLYLHDNT (in Ref. 3; AAA32031)"
FT                   /evidence="ECO:0000305"
FT   HELIX           20..23
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   HELIX           26..28
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   STRAND          36..38
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   STRAND          41..43
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   HELIX           44..53
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   TURN            57..61
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   HELIX           69..72
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   HELIX           74..81
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   TURN            82..84
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   HELIX           85..87
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   HELIX           94..96
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   HELIX           98..101
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   TURN            102..104
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   HELIX           106..116
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   TURN            117..120
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   STRAND          121..124
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   TURN            125..128
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   TURN            139..150
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   HELIX           151..179
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   HELIX           187..201
FT                   /evidence="ECO:0007829|PDB:6J5I"
FT   HELIX           207..221
FT                   /evidence="ECO:0007829|PDB:6J5I"
SQ   SEQUENCE   226 AA;  25039 MW;  BE197F3B086FEEA2 CRC64;
     MNENLFASFI APTMMGLPIV TLIIMFPSLL FPTPKRLINN RTISIQQWLI QLTSKQMMAI
     HNQKGQTWSL MLMSLIMFIG STNILGLLPH SFTPTTQLSM NLGMAIPLWS ATVFTGFRYK
     TKTSLAHFLP QGTPALLIPM LVIIETISLF IQPVALAVRL TANITAGHLL IHLIGGATLA
     LLNINTMTAF ITFTILILLT ILEFAVALIQ AYVFTLLVSL YLHDNT
 
 
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