ID   PURR_LACLA              Reviewed;         271 AA.
AC   P0A3Z9; O53065;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Pur operon repressor;
GN   Name=purR; OrderedLocusNames=LL2259; ORFNames=L134453;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: Controls the transcription of the pur operon for purine
CC       biosynthetic genes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. {ECO:0000305}.
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DR   EMBL; AE005176; AAK06357.1; -; Genomic_DNA.
DR   PIR; C86907; C86907.
DR   RefSeq; NP_268416.1; NC_002662.1.
DR   RefSeq; WP_010906422.1; NC_002662.1.
DR   AlphaFoldDB; P0A3Z9; -.
DR   SMR; P0A3Z9; -.
DR   STRING; 272623.L134453; -.
DR   PaxDb; P0A3Z9; -.
DR   EnsemblBacteria; AAK06357; AAK06357; L134453.
DR   GeneID; 60356502; -.
DR   GeneID; 61110602; -.
DR   GeneID; 66443258; -.
DR   KEGG; lla:L134453; -.
DR   PATRIC; fig|272623.7.peg.2424; -.
DR   eggNOG; COG0503; Bacteria.
DR   HOGENOM; CLU_088227_0_0_9; -.
DR   OMA; YMLERPR; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045982; P:negative regulation of purine nucleobase metabolic process; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR015265; PuR_N.
DR   InterPro; IPR010078; PurR_Bsub.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43864:SF2; PTHR43864:SF2; 1.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   Pfam; PF09182; PuR_N; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF53271; SSF53271; 1.
DR   TIGRFAMs; TIGR01743; purR_Bsub; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..271
FT                   /note="Pur operon repressor"
FT                   /id="PRO_0000139700"
SQ   SEQUENCE   271 AA;  30361 MW;  04614AA24E1C4BCD CRC64;
     MKRNERLVDF TNFLINHPNQ MLNLNELSKH YEVAKSSISE DLVFIKRVFE NQGVGLVETF
     PGSLGGVRFT PYITDERSLE MSQEIAELLR EENRILPGGY IYLSDILGTP SNLRKIGQII
     AHEYHEKQVD VVMTIATKGI PIAQSVAEIL DVPFVIVRRD PKVTEGATLN VNYMSGSSSR
     VENMTLSKRS LSIGQNVLIV DDFMKGAGTI NGMRSLVHEF DCLLAGVAVF LEGPFKGERL
     IDDYKSILKV DRIDIANRSI DVQLGNIFND K