ID   PURR_LACLM              Reviewed;         271 AA.
AC   P0A400; A2RP67; O53065;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Pur operon repressor;
GN   Name=purR; OrderedLocusNames=llmg_2551;
OS   Lactococcus lactis subsp. cremoris (strain MG1363).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus; Lactococcus cremoris subsp. cremoris.
OX   NCBI_TaxID=416870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Kilstrup M.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MG1363;
RX   PubMed=17307855; DOI=10.1128/jb.01768-06;
RA   Wegmann U., O'Connell-Motherway M., Zomer A., Buist G., Shearman C.,
RA   Canchaya C., Ventura M., Goesmann A., Gasson M.J., Kuipers O.P.,
RA   van Sinderen D., Kok J.;
RT   "The complete genome sequence of the lactic acid bacterial paradigm
RT   Lactococcus lactis subsp. cremoris MG1363.";
RL   J. Bacteriol. 189:3256-3270(2007).
CC   -!- FUNCTION: Controls the transcription of the pur operon for purine
CC       biosynthetic genes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. {ECO:0000305}.
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DR   EMBL; AJ222642; CAA10902.1; -; Genomic_DNA.
DR   EMBL; AM406671; CAL99113.1; -; Genomic_DNA.
DR   RefSeq; WP_010906422.1; NZ_WJVF01000037.1.
DR   AlphaFoldDB; P0A400; -.
DR   SMR; P0A400; -.
DR   STRING; 416870.llmg_2551; -.
DR   EnsemblBacteria; CAL99113; CAL99113; llmg_2551.
DR   GeneID; 60356502; -.
DR   GeneID; 61110602; -.
DR   GeneID; 66443258; -.
DR   KEGG; llm:llmg_2551; -.
DR   eggNOG; COG0503; Bacteria.
DR   HOGENOM; CLU_088227_0_0_9; -.
DR   OMA; YMLERPR; -.
DR   PhylomeDB; P0A400; -.
DR   BioCyc; LLAC416870:LLMG_RS12865-MON; -.
DR   Proteomes; UP000000364; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045982; P:negative regulation of purine nucleobase metabolic process; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR015265; PuR_N.
DR   InterPro; IPR010078; PurR_Bsub.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43864:SF2; PTHR43864:SF2; 1.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   Pfam; PF09182; PuR_N; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF53271; SSF53271; 1.
DR   TIGRFAMs; TIGR01743; purR_Bsub; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..271
FT                   /note="Pur operon repressor"
FT                   /id="PRO_0000139701"
SQ   SEQUENCE   271 AA;  30361 MW;  04614AA24E1C4BCD CRC64;
     MKRNERLVDF TNFLINHPNQ MLNLNELSKH YEVAKSSISE DLVFIKRVFE NQGVGLVETF
     PGSLGGVRFT PYITDERSLE MSQEIAELLR EENRILPGGY IYLSDILGTP SNLRKIGQII
     AHEYHEKQVD VVMTIATKGI PIAQSVAEIL DVPFVIVRRD PKVTEGATLN VNYMSGSSSR
     VENMTLSKRS LSIGQNVLIV DDFMKGAGTI NGMRSLVHEF DCLLAGVAVF LEGPFKGERL
     IDDYKSILKV DRIDIANRSI DVQLGNIFND K