ID   PURR_STRPN              Reviewed;         275 AA.
AC   P65832; Q97NP1;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Pur operon repressor;
GN   Name=purR; OrderedLocusNames=SP_1979;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- FUNCTION: Controls the transcription of the pur operon for purine
CC       biosynthetic genes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. {ECO:0000305}.
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DR   EMBL; AE005672; AAK76046.1; -; Genomic_DNA.
DR   PIR; E95231; E95231.
DR   RefSeq; WP_001809310.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; P65832; -.
DR   SMR; P65832; -.
DR   STRING; 170187.SP_1979; -.
DR   EnsemblBacteria; AAK76046; AAK76046; SP_1979.
DR   GeneID; 60232547; -.
DR   GeneID; 66807041; -.
DR   KEGG; spn:SP_1979; -.
DR   eggNOG; COG0503; Bacteria.
DR   OMA; YMLERPR; -.
DR   PhylomeDB; P65832; -.
DR   BioCyc; SPNE170187:G1FZB-2033-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045982; P:negative regulation of purine nucleobase metabolic process; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR015265; PuR_N.
DR   InterPro; IPR010078; PurR_Bsub.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43864:SF2; PTHR43864:SF2; 1.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   Pfam; PF09182; PuR_N; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF53271; SSF53271; 1.
DR   TIGRFAMs; TIGR01743; purR_Bsub; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..275
FT                   /note="Pur operon repressor"
FT                   /id="PRO_0000139702"
SQ   SEQUENCE   275 AA;  30227 MW;  DC64763E4E03E5FC CRC64;
     MKLRRSDRMV VISNYLINNP YKLTSLNTFA EKYESAKSSI SEDIVIIKRA FEEIEIGHIQ
     TVTGAGGGVI FTPSISSQDA KEMVEDLRTK LSESDRILPG GYIYLSDLLS TPAILKNIGR
     IIAKSFMDQK IDAVMTVATK GVPLANAVAN VLNVSFVIVR RDLKITEGST VSVNYVSGSS
     GDRIEKMFLS KRSLKAGSRV LIVDDFLKGG GTVNGMISLL REFDSELAGV AVFADNAQEE
     REKQFDYKSL LKVTNIDVKN QAIDVEVGNI FDEDK