ID   PURR_STRR6              Reviewed;         275 AA.
AC   P65833; Q97NP1;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 96.
DE   RecName: Full=Pur operon repressor;
GN   Name=purR; OrderedLocusNames=spr1793;
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6;
RX   PubMed=11544234; DOI=10.1128/jb.183.19.5709-5717.2001;
RA   Hoskins J., Alborn W.E. Jr., Arnold J., Blaszczak L.C., Burgett S.,
RA   DeHoff B.S., Estrem S.T., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A.R., Lagace R.E., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S.M., McHenney M.,
RA   McLeaster K., Mundy C.W., Nicas T.I., Norris F.H., O'Gara M., Peery R.B.,
RA   Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA   Young-Bellido M., Zhao G., Zook C.A., Baltz R.H., Jaskunas S.R.,
RA   Rosteck P.R. Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
CC   -!- FUNCTION: Controls the transcription of the pur operon for purine
CC       biosynthetic genes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. {ECO:0000305}.
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DR   EMBL; AE007317; AAL00596.1; -; Genomic_DNA.
DR   PIR; G98095; G98095.
DR   RefSeq; NP_359385.1; NC_003098.1.
DR   RefSeq; WP_001809310.1; NC_003098.1.
DR   AlphaFoldDB; P65833; -.
DR   SMR; P65833; -.
DR   STRING; 171101.spr1793; -.
DR   EnsemblBacteria; AAL00596; AAL00596; spr1793.
DR   GeneID; 60232547; -.
DR   GeneID; 66807041; -.
DR   KEGG; spr:spr1793; -.
DR   PATRIC; fig|171101.6.peg.1935; -.
DR   eggNOG; COG0503; Bacteria.
DR   HOGENOM; CLU_088227_0_0_9; -.
DR   OMA; YMLERPR; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045982; P:negative regulation of purine nucleobase metabolic process; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06223; PRTases_typeI; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.40.50.2020; -; 1.
DR   InterPro; IPR000836; PRibTrfase_dom.
DR   InterPro; IPR029057; PRTase-like.
DR   InterPro; IPR015265; PuR_N.
DR   InterPro; IPR010078; PurR_Bsub.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43864:SF2; PTHR43864:SF2; 1.
DR   Pfam; PF00156; Pribosyltran; 1.
DR   Pfam; PF09182; PuR_N; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF53271; SSF53271; 1.
DR   TIGRFAMs; TIGR01743; purR_Bsub; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..275
FT                   /note="Pur operon repressor"
FT                   /id="PRO_0000139703"
SQ   SEQUENCE   275 AA;  30227 MW;  DC64763E4E03E5FC CRC64;
     MKLRRSDRMV VISNYLINNP YKLTSLNTFA EKYESAKSSI SEDIVIIKRA FEEIEIGHIQ
     TVTGAGGGVI FTPSISSQDA KEMVEDLRTK LSESDRILPG GYIYLSDLLS TPAILKNIGR
     IIAKSFMDQK IDAVMTVATK GVPLANAVAN VLNVSFVIVR RDLKITEGST VSVNYVSGSS
     GDRIEKMFLS KRSLKAGSRV LIVDDFLKGG GTVNGMISLL REFDSELAGV AVFADNAQEE
     REKQFDYKSL LKVTNIDVKN QAIDVEVGNI FDEDK