ID   PUS7_ORYSJ              Reviewed;         393 AA.
AC   Q0E0Y3;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 2.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=RNA pseudouridine synthase 7;
DE            EC=5.4.99.-;
DE   AltName: Full=RNA pseudouridylate synthase 7;
DE   AltName: Full=RNA-uridine isomerase 7;
GN   OrderedLocusNames=Os02g0512300, LOC_Os02g30840;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a uridine in RNA = a pseudouridine in RNA;
CC         Xref=Rhea:RHEA:48348, Rhea:RHEA-COMP:12068, Rhea:RHEA-COMP:12069,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase RluA family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAF08855.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AP008208; BAF08855.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP014958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_015623095.1; XM_015767609.1.
DR   AlphaFoldDB; Q0E0Y3; -.
DR   SMR; Q0E0Y3; -.
DR   STRING; 4530.OS02T0512300-01; -.
DR   PaxDb; Q0E0Y3; -.
DR   PRIDE; Q0E0Y3; -.
DR   GeneID; 9269812; -.
DR   KEGG; osa:9269812; -.
DR   eggNOG; KOG1919; Eukaryota.
DR   InParanoid; Q0E0Y3; -.
DR   OrthoDB; 821308at2759; -.
DR   Proteomes; UP000000763; Chromosome 2.
DR   Proteomes; UP000059680; Chromosome 2.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000455; P:enzyme-directed rRNA pseudouridine synthesis; IBA:GO_Central.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR006225; PsdUridine_synth_RluC/D.
DR   InterPro; IPR006224; PsdUridine_synth_RluC/D_CS.
DR   InterPro; IPR006145; PsdUridine_synth_RsuA/RluA.
DR   Pfam; PF00849; PseudoU_synth_2; 1.
DR   SUPFAM; SSF55120; SSF55120; 1.
DR   TIGRFAMs; TIGR00005; rluA_subfam; 1.
DR   PROSITE; PS01129; PSI_RLU; 1.
PE   2: Evidence at transcript level;
KW   Isomerase; Reference proteome; RNA-binding.
FT   CHAIN           1..393
FT                   /note="RNA pseudouridine synthase 7"
FT                   /id="PRO_0000368028"
FT   DOMAIN          49..118
FT                   /note="S4 RNA-binding"
FT   ACT_SITE        162
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   393 AA;  44059 MW;  557355F53E435F6D CRC64;
     MAAGPAGIVW QTPANPPERQ DYIFRDGRRY VRPYYFEFIS HVKNRWAGKT IVDLFTDEFK
     GRPREYYVHA VKCGRLQVDD QMVHADYVVQ SSQKISHFLH RHEPPVLGGD ITILQNEADV
     VTVCKPASVP VHPCGQYRKN TVVGILQAEH GLVPLFPVHR LDRLVSGLLI FAKNADKAES
     FRQQIEASLL QKEYVAKVVG VFPDGEQTVN ANVHFNAREG RSTAEVCDGD GKAPIGKQAC
     TKFQRICTDG IHSIVLCKPV TGRTHQIRVH LKHIGYPIAN DEVYLSENFS PRSSKGTRIN
     RATTLACSLP SSDPDSCADL GNNDTNEDTE ADEEFSIDPM CTNCPNLAPV GYDADEEALW
     LHCVRYTGPD WSYECPYPDW AFLDNVSRKK LKS