PUTP_HAEIN
ID PUTP_HAEIN Reviewed; 504 AA.
AC P45174;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Sodium/proline symporter {ECO:0000250|UniProtKB:P07117};
DE AltName: Full=Proline permease;
GN Name=putP; OrderedLocusNames=HI_1352;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- FUNCTION: Catalyzes the sodium-dependent uptake of extracellular L-
CC proline. {ECO:0000250|UniProtKB:P07117}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-proline(in) + Na(+)(in) = L-proline(out) + Na(+)(out);
CC Xref=Rhea:RHEA:28967, ChEBI:CHEBI:29101, ChEBI:CHEBI:60039;
CC Evidence={ECO:0000250|UniProtKB:P07117};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000250|UniProtKB:P07117}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000305}.
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DR EMBL; L42023; AAC22999.1; -; Genomic_DNA.
DR PIR; E64118; E64118.
DR RefSeq; NP_439503.1; NC_000907.1.
DR RefSeq; WP_010869188.1; NC_000907.1.
DR AlphaFoldDB; P45174; -.
DR SMR; P45174; -.
DR STRING; 71421.HI_1352; -.
DR EnsemblBacteria; AAC22999; AAC22999; HI_1352.
DR KEGG; hin:HI_1352; -.
DR PATRIC; fig|71421.8.peg.1405; -.
DR eggNOG; COG0591; Bacteria.
DR HOGENOM; CLU_018808_15_2_6; -.
DR OMA; CWTDLIQ; -.
DR PhylomeDB; P45174; -.
DR BioCyc; HINF71421:G1GJ1-1377-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005298; F:proline:sodium symporter activity; IBA:GO_Central.
DR GO; GO:0031402; F:sodium ion binding; IEA:InterPro.
DR GO; GO:0015824; P:proline transport; IEA:InterPro.
DR CDD; cd11475; SLC5sbd_PutP; 1.
DR Gene3D; 1.20.1730.10; -; 1.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR011851; Na/Pro_symporter.
DR InterPro; IPR001734; Na/solute_symporter.
DR InterPro; IPR018212; Na/solute_symporter_CS.
DR Pfam; PF00474; SSF; 1.
DR TIGRFAMs; TIGR02121; Na_Pro_sym; 1.
DR TIGRFAMs; TIGR00813; sss; 1.
DR PROSITE; PS00456; NA_SOLUT_SYMP_1; 1.
DR PROSITE; PS00457; NA_SOLUT_SYMP_2; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell inner membrane; Cell membrane; Ion transport;
KW Membrane; Reference proteome; Sodium; Sodium transport; Symport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..504
FT /note="Sodium/proline symporter"
FT /id="PRO_0000105399"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 324..344
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 374..394
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 434..454
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 504 AA; 54899 MW; 61ED0A52A142A7F0 CRC64;
MFGFDPSLIT FTIYIFGMLL IGVLAYYYTN NLSDYILGGR RLGSFVTAMS AGASDMSGWL
LMGLPGAVYL SGLVEGWIAI GLTIGAYFNW LLVAGRLRVY TELNNNALTL PEYFHNRFGS
SHKLLKLVSA TIILVFLTIY CASGVVAGAK LFQNIFSVEY STALWYGAAA TIAYTFIGGF
LAVSWTDTIQ ATLMIFALIL TPVFVLLSFA DTAQFSAVLE QAEAAVNKDF TDLFTSTTPL
GLLSLAAWGL GYFGQPHILA RFMAADSVKS LIKARRISMG WMVLCLAGAI GIGLFAIPYF
FANPAIAGTV NREPEQVFIE LAKLLFNPWI AGILLSAILA AVMSTLSAQL LISSSSITED
FYKGFIRPNA SEKELVWLGR IMVLVIAALA IWIAQDENSK VLKLVEFAWA GFGSAFGPVV
LFSLFWKRMT SSGAMAGMLV GAVTVFAWKE VVPADTDWFK VYEMIPGFAF ASLAIIVISL
LSNKPEQDIL NTFDKAEKAY KEAK
