ID   PUUR_SHIFL              Reviewed;         185 AA.
AC   P0A9U7; P38522; P76839; P77417;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=HTH-type transcriptional regulator PuuR;
GN   Name=puuR; OrderedLocusNames=SF1304, S1386;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Represses puuD. {ECO:0000250}.
CC   -!- PATHWAY: Amine and polyamine degradation; putrescine degradation
CC       [regulation].
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE005674; AAN42915.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP16797.1; -; Genomic_DNA.
DR   RefSeq; NP_707208.1; NC_004337.2.
DR   RefSeq; WP_001278727.1; NZ_WPGW01000009.1.
DR   AlphaFoldDB; P0A9U7; -.
DR   SMR; P0A9U7; -.
DR   STRING; 198214.SF1304; -.
DR   EnsemblBacteria; AAN42915; AAN42915; SF1304.
DR   EnsemblBacteria; AAP16797; AAP16797; S1386.
DR   GeneID; 1024243; -.
DR   GeneID; 67417375; -.
DR   KEGG; sfl:SF1304; -.
DR   KEGG; sfx:S1386; -.
DR   PATRIC; fig|198214.7.peg.1530; -.
DR   HOGENOM; CLU_085376_1_4_6; -.
DR   OMA; VELLFVH; -.
DR   OrthoDB; 1292067at2; -.
DR   UniPathway; UPA00188; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009447; P:putrescine catabolic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   Gene3D; 2.60.120.10; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR013096; Cupin_2.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   Pfam; PF07883; Cupin_2; 1.
DR   Pfam; PF01381; HTH_3; 1.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   SUPFAM; SSF51182; SSF51182; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..185
FT                   /note="HTH-type transcriptional regulator PuuR"
FT                   /id="PRO_0000149732"
FT   DOMAIN          12..66
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   185 AA;  20092 MW;  D7D0D3FD794A7768 CRC64;
     MSDEGLAPGK RLSEIRQQQG LSQRRAAELS GLTHSAISTI EQDKVSPAIS TLQKLLKVYG
     LSLSEFFSEP EKPDEPQVVI NQDDLIEMGS QGVSMKLVHN GNPNRTLAMI FETYQPGTTT
     GERIKHQGEE IGTVLEGEIV LTINGQDYHL VAGQSYAINT GIPHSFSNTS AGICRIISAH
     TPTTF