ID   PVAA_STRP1              Reviewed;         199 AA.
AC   Q99ZN9; Q48YT5;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 108.
DE   RecName: Full=Pneumococcal vaccine antigen A homolog;
GN   Name=pvaA; OrderedLocusNames=SPy_1147, M5005_Spy0869;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000250}.
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DR   EMBL; AE004092; AAK34019.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ51487.1; -; Genomic_DNA.
DR   RefSeq; NP_269298.1; NC_002737.2.
DR   AlphaFoldDB; Q99ZN9; -.
DR   SMR; Q99ZN9; -.
DR   STRING; 1314.HKU360_00931; -.
DR   PaxDb; Q99ZN9; -.
DR   EnsemblBacteria; AAK34019; AAK34019; SPy_1147.
DR   KEGG; spy:SPy_1147; -.
DR   KEGG; spz:M5005_Spy0869; -.
DR   PATRIC; fig|160490.10.peg.1000; -.
DR   HOGENOM; CLU_101375_3_0_9; -.
DR   OMA; GNMFYAD; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   SUPFAM; SSF53955; SSF53955; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..199
FT                   /note="Pneumococcal vaccine antigen A homolog"
FT                   /id="PRO_0000097111"
SQ   SEQUENCE   199 AA;  22072 MW;  B4556653B96C1A89 CRC64;
     MFRLLKRACS FLLLFVIYQS FVIHHNVQRV LAYKPMVEKT LAENDTKANV DLVLAMIYTE
     TKGGEADVMQ SSESSSGQKN SITDSQASIE HGVNLLSHNL ALAEEAGVDS WTAVQAYNFG
     TAYIDYIAEH GGQNTVDLAT TYSKTVVAPS LGNTSGQTYF YYHPLALISG GKLYKNGGNI
     YYSREVHFNL YLIELMSLF