ID   PVAA_STRPN              Reviewed;         204 AA.
AC   Q9AHT6;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Pneumococcal vaccine antigen A;
GN   Name=pvaA; OrderedLocusNames=SP_1026;
OS   Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=170187;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=N4;
RX   PubMed=11179332; DOI=10.1128/iai.69.3.1593-1598.2001;
RA   Wizemann T.M., Heinrichs J.H., Adamou J.E., Erwin A.L., Kunsch C.,
RA   Choi G.H., Barash S.C., Rosen C.A., Masure H.R., Tuomanen E., Gayle A.,
RA   Brewah Y.A., Walsh W., Barren P., Lathigra R., Hanson M., Langermann S.,
RA   Johnson S., Koenig S.;
RT   "Use of a whole genome approach to identify vaccine molecules affording
RT   protection against Streptococcus pneumoniae infection.";
RL   Infect. Immun. 69:1593-1598(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-334 / TIGR4;
RX   PubMed=11463916; DOI=10.1126/science.1061217;
RA   Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA   Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA   Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA   Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA   Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA   McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA   Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA   Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT   "Complete genome sequence of a virulent isolate of Streptococcus
RT   pneumoniae.";
RL   Science 293:498-506(2001).
CC   -!- SUBCELLULAR LOCATION: Cell surface {ECO:0000305}.
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DR   EMBL; AF291698; AAK19158.1; -; Genomic_DNA.
DR   EMBL; AE005672; AAK75141.1; -; Genomic_DNA.
DR   PIR; D95118; D95118.
DR   RefSeq; WP_000476386.1; NZ_AKVY01000001.1.
DR   AlphaFoldDB; Q9AHT6; -.
DR   SMR; Q9AHT6; -.
DR   STRING; 170187.SP_1026; -.
DR   CAZy; GH23; Glycoside Hydrolase Family 23.
DR   DNASU; 931540; -.
DR   EnsemblBacteria; AAK75141; AAK75141; SP_1026.
DR   KEGG; spn:SP_1026; -.
DR   eggNOG; COG0741; Bacteria.
DR   OMA; GNMFYAD; -.
DR   PhylomeDB; Q9AHT6; -.
DR   BioCyc; SPNE170187:G1FZB-1056-MON; -.
DR   Proteomes; UP000000585; Chromosome.
DR   GO; GO:0009986; C:cell surface; IEA:UniProtKB-SubCell.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   SUPFAM; SSF53955; SSF53955; 1.
PE   4: Predicted;
FT   CHAIN           1..204
FT                   /note="Pneumococcal vaccine antigen A"
FT                   /id="PRO_0000097115"
SQ   SEQUENCE   204 AA;  22970 MW;  019E859869259149 CRC64;
     MFKRIRRVLV LAVFLFAGYK AYRVHQDVKQ VMTYQPMVRE ILSEQDTPAN EELVLAMIYT
     ETKGKEGDVM QSSESASGST NTINDNASSI RQGIQTLTGN LYLAQKKGVD IWTAVQAYNF
     GPAYIDFIAQ NGKENTLALA KQYSRETVAP LLGNRTGKTY SYIHPISIFH GAELYVNGGN
     YYYSRQVRLN LYIIKCFTLF STSG