PVDB_PLAKN
ID PVDB_PLAKN Reviewed; 1153 AA.
AC P50493;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Duffy receptor beta form;
DE AltName: Full=Erythrocyte-binding protein;
DE Flags: Precursor;
OS Plasmodium knowlesi.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Plasmodium).
OX NCBI_TaxID=5850;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1496004; DOI=10.1073/pnas.89.15.7085;
RA Adams J.H., Sim B.K., Dolan S.A., Fang X., Kaslow D.C., Miller L.H.;
RT "A family of erythrocyte binding proteins of malaria parasites.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:7085-7089(1992).
CC -!- FUNCTION: Binds to the human erythrocytes Duffy blood group
CC determinant.
CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
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DR EMBL; M90694; AAA29603.1; -; Genomic_DNA.
DR PIR; T28652; T28652.
DR AlphaFoldDB; P50493; -.
DR SMR; P50493; -.
DR VEuPathDB; PlasmoDB:PKA1H_140005700; -.
DR VEuPathDB; PlasmoDB:PKNH_1400800; -.
DR VEuPathDB; PlasmoDB:PKNOH_S140217900; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0046789; F:host cell surface receptor binding; IEA:InterPro.
DR Gene3D; 1.10.1740.170; -; 1.
DR Gene3D; 1.20.1310.20; -; 1.
DR InterPro; IPR004258; DBL.
DR InterPro; IPR042202; Duffy-ag-bd_sf.
DR InterPro; IPR008602; Duffy-antigen-binding.
DR InterPro; IPR021015; Duffy-antigen-binding_C.
DR InterPro; IPR021032; Duffy-antigen-binding_N.
DR InterPro; IPR021620; EBA-175_C.
DR InterPro; IPR043057; EBA-175_C_sf.
DR Pfam; PF12361; DBP; 2.
DR Pfam; PF05424; Duffy_binding; 1.
DR Pfam; PF12377; DuffyBP_N; 1.
DR Pfam; PF11556; EBA-175_VI; 1.
DR Pfam; PF03011; PFEMP; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Glycoprotein; Malaria; Membrane; Receptor; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..1153
FT /note="Duffy receptor beta form"
FT /id="PRO_0000024619"
FT TOPO_DOM 22..1085
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 1086..1106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1107..1153
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 520..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..631
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 655..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 527..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..673
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 800..863
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 864..878
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..941
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..966
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 967..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 179
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 202
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 252
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 348
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 430
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 467
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 576
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 626
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 722
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 847
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 856
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 900
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 910
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 935
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 214..243
FT /evidence="ECO:0000250"
FT DISULFID 227..234
FT /evidence="ECO:0000250"
FT DISULFID 297..374
FT /evidence="ECO:0000250"
FT DISULFID 412..429
FT /evidence="ECO:0000250"
FT DISULFID 424..504
FT /evidence="ECO:0000250"
FT DISULFID 433..502
FT /evidence="ECO:0000250"
SQ SEQUENCE 1153 AA; 130472 MW; 6497BD16CE7BEC01 CRC64;
MEGKKKRPLF FLLVLLLSHK ANNVLFERMK GILLLECENE YVKNENGYKL ATGHHYMDND
QIERWLQGTD RSRRVKIEEN VKYKYNVEEL NTKYEQTKGK RINRILKEST YEAQNVADNN
YIDDKANGEY KTDNKTNKGE GARNMVMLDY DISGSGHPDG IIDNVVELGT EDEGNFLENS
SKGGDHPYRM NRKERMCSGV INQTFLQKNV MRRCNNKRKR GTRDWDCPTK KDVCIPDRRY
QLCMKELTNL VNNTKTHSHN DITFLKLNLK EKLTYDAAVE GDLLLKKYNN VYSEDLCKDI
KWSLEDFGDI IMGTDMEGIG YSQVVENNLR TVFGTGTKTQ LDRKKWWNES KKYIWEATIL
SVKKKLNGYS AWNCKEDVQI NVEPQIYRWI REWGMDYMSE LPKEQRKIKE KCDRKLYYTN
LRICTMSPCN DSCKLYDQWI TRKKKQWDVL STKFSSVKKG QIIETENITT AYDILKQELN
GFNEVMFENE INKRDNVYID ICLCAADEPN KNTQEHLKKL KSAPKLETQR SHSTIQPMSS
SGAEKVQGDL AHGNINDAAY KSTTDEAAKG DGQNGNQTVA ESNIKGTDNI ENEAAKNVDT
YKFVTERSAD TRGATDITET GEEKLNTSYS GSSEITVKEN IPGDGIVKDV SAAVENSENP
LETKHKIFEP SKDNSDNSEN SGSMEFKATS SNPITEAVES SSAEGQVQED SAHRSVNTGR
DNSTISAATS DDGLSSGDKR VESLTSIENA DDGGDPVQGS LWNLLNDPSV GAGGGKSHIK
TEENEGSQAE IDGKNVDIAE QRTATITEVQ PERPDLSDTD NGNVPRSGNK QNEGATALSG
AESLESNESV HKTIDNTTHG LENKNGGNEK DFQKHDFMNN DMLNDQTSSD QTSSDQTSSN
QTSSDQTSSN QTSSDQTSSD QISSDQTSSD QTSSNQTSSD QTIDTEEHHR DNVRNPEIKS
SEDMSKGDFM RNSNSNELYS HNNLNNRKLN IDQYEHRDVK ATREKIILMS EVNKCNNRAS
LKYCNTIEDR MLSSTCSRER SKNLCCSISD FCLNYFELYP YEFYNCMKKE FEDSSYECFT
KGSSTGIGIV YFATGGAFLI ILLLFVSKNV ASNDYEEEAT FDEFVEYSDD IHRTPLMPNH
IEHMQQFTPL DYS
