PVG2_SCHPO
ID PVG2_SCHPO Reviewed; 389 AA.
AC O14001;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Pyruvylated Gal-beta-1,3-epitope synthesis protein 2;
DE Short=PvGal synthesis protein 2;
DE AltName: Full=Meiotically up-regulated gene 53 protein;
GN Name=pvg2; Synonyms=mug53; ORFNames=SPAC27E2.07;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION.
RX PubMed=15173185; DOI=10.1074/jbc.m403574200;
RA Andreishcheva E.N., Kunkel J.P., Gemmill T.R., Trimble R.B.;
RT "Five genes involved in biosynthesis of the pyruvylated Galbeta1,3-epitope
RT in Schizosaccharomyces pombe N-linked glycans.";
RL J. Biol. Chem. 279:35644-35655(2004).
RN [3]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
CC -!- FUNCTION: Involved in cell wall biogenesis. Has a role in the addition
CC of Gal-beta1,3 moeities to galactomannans and their subsequent
CC pyruvylation. Has a role in meiosis. {ECO:0000269|PubMed:15173185,
CC ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type
CC II membrane protein. Golgi apparatus membrane; Single-pass type II
CC membrane protein. Note=Recycles between endoplasmic reticulum and
CC Golgi. {ECO:0000305}.
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DR EMBL; CU329670; CAB11681.1; -; Genomic_DNA.
DR PIR; T38455; T38455.
DR RefSeq; NP_594408.1; NM_001019839.2.
DR AlphaFoldDB; O14001; -.
DR BioGRID; 278392; 29.
DR STRING; 4896.SPAC27E2.07.1; -.
DR MaxQB; O14001; -.
DR PaxDb; O14001; -.
DR EnsemblFungi; SPAC27E2.07.1; SPAC27E2.07.1:pep; SPAC27E2.07.
DR GeneID; 2541902; -.
DR KEGG; spo:SPAC27E2.07; -.
DR PomBase; SPAC27E2.07; pvg2.
DR VEuPathDB; FungiDB:SPAC27E2.07; -.
DR HOGENOM; CLU_708152_0_0_1; -.
DR OMA; ESSDICF; -.
DR PRO; PR:O14001; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0051286; C:cell tip; IDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0000030; F:mannosyltransferase activity; IBA:GO_Central.
DR GO; GO:0051072; P:4,6-pyruvylated galactose residue biosynthetic process; IMP:PomBase.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0009272; P:fungal-type cell wall biogenesis; IC:PomBase.
DR GO; GO:0051999; P:mannosyl-inositol phosphorylceramide biosynthetic process; IBA:GO_Central.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Cell wall biogenesis/degradation; Endoplasmic reticulum; Golgi apparatus;
KW Meiosis; Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..389
FT /note="Pyruvylated Gal-beta-1,3-epitope synthesis protein
FT 2"
FT /id="PRO_0000076295"
FT TOPO_DOM 1..16
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..389
FT /note="Lumenal"
FT /evidence="ECO:0000255"
SQ SEQUENCE 389 AA; 45065 MW; 9579460D7C28DAEF CRC64;
MTKLWVNFFS QKLLRLLIPS IIVVFAFAAL FAIYSPIQLG GINFYKRTNL FTVEELGEKE
LELSKTVTID IYRKAMCMDD LEQSRKCTTF GLDPPISAHL FYTYNRDTGM NRVARQWNRR
IPRVFHTIKG SNFIELSQFT AFEVELRVSH PNWAFVSWSH DDLNELVDKS YHNLHNAWSQ
LSREAKDQWG FLLGLYEYGG VWMSRSLQLK KNIDKFVYAA ELSVKQFTEN ITSSTVEEFQ
PIFMAPKSLQ YDFMIATPKH PFVLSLINEL CKSEVLLKIL SKRPYHGLDA AEALFAENRE
SITIREQEFF VNTYIDDGKV FVKNNPHIIF IPTEAFASTW DFLPSEESSE MCFADSPLFD
PDYCISHSSK PDGNELAIYW SNSFDLITA
