PVG5_SCHPO
ID PVG5_SCHPO Reviewed; 372 AA.
AC Q9UUJ0;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 93.
DE RecName: Full=Pyruvylated Gal-beta-1,3-epitope synthesis protein 5;
DE Short=PvGal synthesis protein 5;
DE AltName: Full=Meiotically up-regulated gene 50 protein;
GN Name=pvg5; Synonyms=mug50; ORFNames=SPAC22F8.02c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP FUNCTION.
RX PubMed=15173185; DOI=10.1074/jbc.m403574200;
RA Andreishcheva E.N., Kunkel J.P., Gemmill T.R., Trimble R.B.;
RT "Five genes involved in biosynthesis of the pyruvylated Galbeta1,3-epitope
RT in Schizosaccharomyces pombe N-linked glycans.";
RL J. Biol. Chem. 279:35644-35655(2004).
RN [3]
RP FUNCTION IN MEIOSIS.
RX PubMed=16303567; DOI=10.1016/j.cub.2005.10.038;
RA Martin-Castellanos C., Blanco M., Rozalen A.E., Perez-Hidalgo L.,
RA Garcia A.I., Conde F., Mata J., Ellermeier C., Davis L., San-Segundo P.,
RA Smith G.R., Moreno S.;
RT "A large-scale screen in S. pombe identifies seven novel genes required for
RT critical meiotic events.";
RL Curr. Biol. 15:2056-2062(2005).
CC -!- FUNCTION: Involved in cell wall biogenesis. Has a role in the addition
CC of Gal-beta1,3 moeities to galactomannans and their subsequent
CC pyruvylation. Has a role in meiosis. {ECO:0000269|PubMed:15173185,
CC ECO:0000269|PubMed:16303567}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-
CC pass type II membrane protein {ECO:0000250}.
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DR EMBL; CU329670; CAB52712.1; -; Genomic_DNA.
DR PIR; T38192; T38192.
DR RefSeq; NP_594725.1; NM_001020153.1.
DR AlphaFoldDB; Q9UUJ0; -.
DR SMR; Q9UUJ0; -.
DR BioGRID; 278211; 3.
DR STRING; 4896.SPAC22F8.02c.1; -.
DR MaxQB; Q9UUJ0; -.
DR PaxDb; Q9UUJ0; -.
DR EnsemblFungi; SPAC22F8.02c.1; SPAC22F8.02c.1:pep; SPAC22F8.02c.
DR GeneID; 2541716; -.
DR KEGG; spo:SPAC22F8.02c; -.
DR PomBase; SPAC22F8.02c; pvg5.
DR VEuPathDB; FungiDB:SPAC22F8.02c; -.
DR HOGENOM; CLU_727920_0_0_1; -.
DR OMA; VYIINDY; -.
DR PRO; PR:Q9UUJ0; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0051072; P:4,6-pyruvylated galactose residue biosynthetic process; IMP:PomBase.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0009272; P:fungal-type cell wall biogenesis; IC:PomBase.
DR GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Cell wall biogenesis/degradation; Glycoprotein; Golgi apparatus; Meiosis;
KW Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..372
FT /note="Pyruvylated Gal-beta-1,3-epitope synthesis protein
FT 5"
FT /id="PRO_0000076297"
FT TOPO_DOM 1..12
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..35
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 36..372
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 128
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 372 AA; 43087 MW; 1E64EFF459179E2E CRC64;
MGLPLRIFAG NGIGGWCLRL FLFGSLILLL RPLIFYSNTT MKKLKTEYPI YHRHLSALKR
NFYYTMDAQL GGIRNVVLIN RPCFAASDNF LTLMGQNWYL KERNINVLSD ICFPLSNNAH
DSLPTFNNGS DLFNPLYFAV LNAATPARFT FHLFNHVMDS VVPFDEAKKF KVRSFPINYA
EYADDECQLA LKKIRPIPDK YLVSTRVLSD SRYLELSGAV VAFAPDASSS LLFELADIKQ
HKKTSADILI FLSKDHNLPV SFYDNYKLKY TLHFWQPPSF PDSSTIDDQA KLLFDYVVSQ
VVKYPYFVTD IYQIHLLGVY LNLKHVYLLE NDDVEDAYYE RQWMQAFQRK NVVAVAEELQ
TALRIIEQWK QL
