ID   PVHR_TALVA              Reviewed;         513 AA.
AC   A0A3T0QHS4;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   08-MAY-2019, sequence version 1.
DT   29-SEP-2021, entry version 11.
DE   RecName: Full=Varicidin biosynthesis cluster-specific transcription factor {ECO:0000303|PubMed:30609896};
GN   Name=TF {ECO:0000303|PubMed:30609896};
OS   Talaromyces variabilis (Penicillium variabile).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces.
OX   NCBI_TaxID=28576;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY, AND
RP   PATHWAY.
RC   STRAIN=HXQ-H-1;
RX   PubMed=30609896; DOI=10.1021/jacs.8b12010;
RA   Tan D., Jamieson C.S., Ohashi M., Tang M.C., Houk K.N., Tang Y.;
RT   "Genome-mined Diels-Alderase catalyzes formation of the cis-
RT   octahydrodecalins of varicidin A and B.";
RL   J. Am. Chem. Soc. 141:769-773(2019).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of varicidin A, an
CC       antifungal natural product containing a cis-octahydrodecalin core.
CC       {ECO:0000305|PubMed:30609896}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; MK376933; AZZ09614.1; -; Genomic_DNA.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Metal-binding; Nucleus; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..513
FT                   /note="Varicidin biosynthesis cluster-specific
FT                   transcription factor"
FT                   /id="PRO_0000453352"
FT   DNA_BIND        16..54
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          58..92
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          97..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        67..92
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   513 AA;  56759 MW;  91DB9F402DE32216 CRC64;
     MPSSPGNRQH SLRSACERCR LHKLKCTILP QKRFEGPQEA PEQCTRCARA KAKCVFGRRA
     PPKHRASSSN DRSSVSKGIN STTPATRTMQ PNATGFVSSH RIELPPSPAS NQSSLKHSSV
     WDNLLDKTTP QEPRADFSSF SYPPVPFDLQ SMCLDEVDMA ASALPTTEPN FSSAQREHEF
     SAMSMSPGLG YDNLDELLAL NEQPNISDAS SPLLSETDPS HGMIRLSSLL KEIHETQHNL
     QERSFSCTTS RGLAGYPIGR VLHAAQTFSS MVTNLMRPRV VQTSHTDVQG FNPSLYSSSP
     ESTELPSLHQ EFVSSLEQMK TNALEQSRRL GEDDLDKYAS PCSSTTSLQD TMLDMPIVML
     VFCCFASLSK LYCSVFRFFE KSLHSQSCRA KDSTYVPPLQ DTRTLQLGEL SIENDTEFKV
     LKALRMLLDA FQAAEASLGL PSSLTVLNSN KSTISASAEP AVSDTGSLQH HLRHSLIKQC
     VTFDDRHLER TLTSLVTHVE NLKQLLRVQN GLH