ID   PVHT_TALVA              Reviewed;         547 AA.
AC   A0A3T0QHT2;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   08-MAY-2019, sequence version 1.
DT   23-FEB-2022, entry version 13.
DE   RecName: Full=Varicidin biosynthesis cluster MFS-type transporer {ECO:0000303|PubMed:30609896};
GN   Name=mfs {ECO:0000303|PubMed:30609896};
OS   Talaromyces variabilis (Penicillium variabile).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces.
OX   NCBI_TaxID=28576;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY, AND
RP   PATHWAY.
RC   STRAIN=HXQ-H-1;
RX   PubMed=30609896; DOI=10.1021/jacs.8b12010;
RA   Tan D., Jamieson C.S., Ohashi M., Tang M.C., Houk K.N., Tang Y.;
RT   "Genome-mined Diels-Alderase catalyzes formation of the cis-
RT   octahydrodecalins of varicidin A and B.";
RL   J. Am. Chem. Soc. 141:769-773(2019).
CC   -!- FUNCTION: MFS-type transporer; part of the gene cluster that mediates
CC       the biosynthesis of varicidin A, an antifungal natural product
CC       containing a cis-octahydrodecalin core. {ECO:0000269|PubMed:30609896}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000305}.
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DR   EMBL; MK376933; AZZ09609.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..547
FT                   /note="Varicidin biosynthesis cluster MFS-type transporer"
FT                   /id="PRO_0000453355"
FT   TRANSMEM        47..67
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        224..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        252..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        360..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        422..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        503..523
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..16
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   547 AA;  59692 MW;  095E2D0B6335396E CRC64;
     MTTSTSKNAI SKSSQEDLCS DTKDKGSSGG GNEANAEASK AIQGFRLVLL FVGLALSVFC
     LSLVCISEFI STFLFTRTYP DVFGFGRIVQ SWLRPFRELR PSLIPLTTWR GSAPLTCYPR
     VVFSFLLESC TRSSRYGACS LRRWVFSSWD HSSAHLAPSL LLPGLCPCIV AQSVFTDRAT
     WRWCFWINLP LGGVTAVAVF LFVRLPSPQG GATTFLGLLQ KLDALGTCIL MPLIICLLLA
     LQWGGTTYAW NSWRVVLCLV LFTVLLVAWL YVQYRQGDGG ALPLRIVRQR SIRSAILFTF
     GINGSMFIIV YYVPIWFQAV KDVTAQQSGI NFLACSGSMS VAAIIAGTLV STGEEKQHQG
     QWRIFNYTTL VSIATGLIWR YNPATSTAYC RAGTLVMFGF GAGSGMQMPF IAAQTVLSAS
     DISLGSSLII LIQTMGGAVF LAVSQNLFQS KLIGLLESHP YGVEPEFILD TGASGLRSAV
     QHKYGTKAVE TVLQAYNTAL RQCFLVCIVL ACLTIIADAG MEWKNVRAGK KPAKAPDAHH
     ESKTDIK