PWP1_BOVIN
ID PWP1_BOVIN Reviewed; 500 AA.
AC Q2HJ56;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Periodic tryptophan protein 1 homolog;
GN Name=PWP1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Uterus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Chromatin-associated factor that regulates transcription (By
CC similarity). Regulates Pol I-mediated rRNA biogenesis and, probably,
CC Pol III-mediated transcription (By similarity). Regulates the
CC epigenetic status of rDNA (By similarity).
CC {ECO:0000250|UniProtKB:Q13610}.
CC -!- SUBUNIT: Associates with the RNA polymerase (Pol I) complex. Interacts
CC with POLR1E. {ECO:0000250|UniProtKB:Q13610}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13610}. Nucleus,
CC nucleolus {ECO:0000250|UniProtKB:Q13610}. Chromosome
CC {ECO:0000250|UniProtKB:Q13610}. Note=Associates with chromatin regions
CC of rDNA. {ECO:0000250|UniProtKB:Q13610}.
CC -!- PTM: Phosphorylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat PWP1 family. {ECO:0000305}.
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DR EMBL; BC113302; AAI13303.1; -; mRNA.
DR RefSeq; NP_001039631.1; NM_001046166.1.
DR AlphaFoldDB; Q2HJ56; -.
DR SMR; Q2HJ56; -.
DR STRING; 9913.ENSBTAP00000006109; -.
DR PaxDb; Q2HJ56; -.
DR PRIDE; Q2HJ56; -.
DR Ensembl; ENSBTAT00000006109; ENSBTAP00000006109; ENSBTAG00000004654.
DR GeneID; 514147; -.
DR KEGG; bta:514147; -.
DR CTD; 11137; -.
DR VEuPathDB; HostDB:ENSBTAG00000004654; -.
DR VGNC; VGNC:33580; PWP1.
DR eggNOG; KOG0270; Eukaryota.
DR GeneTree; ENSGT00390000017324; -.
DR HOGENOM; CLU_023867_1_1_1; -.
DR InParanoid; Q2HJ56; -.
DR OMA; CFVPRGV; -.
DR OrthoDB; 737539at2759; -.
DR TreeFam; TF314868; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000004654; Expressed in oocyte and 105 other tissues.
DR ExpressionAtlas; Q2HJ56; baseline and differential.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1990889; F:H4K20me3 modified histone binding; IEA:Ensembl.
DR GO; GO:0034773; P:histone H4-K20 trimethylation; IEA:Ensembl.
DR GO; GO:0033140; P:negative regulation of peptidyl-serine phosphorylation of STAT protein; IEA:Ensembl.
DR GO; GO:2000738; P:positive regulation of stem cell differentiation; IEA:Ensembl.
DR GO; GO:1901838; P:positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; IEA:Ensembl.
DR GO; GO:0006364; P:rRNA processing; IEA:InterPro.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR044285; PWP1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR14091; PTHR14091; 1.
DR Pfam; PF00400; WD40; 2.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Chromosome; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW Ribosome biogenesis; Transcription; Transcription regulation; WD repeat.
FT CHAIN 1..500
FT /note="Periodic tryptophan protein 1 homolog"
FT /id="PRO_0000244987"
FT REPEAT 185..229
FT /note="WD 1"
FT REPEAT 253..293
FT /note="WD 2"
FT REPEAT 296..336
FT /note="WD 3"
FT REPEAT 382..422
FT /note="WD 4"
FT REPEAT 427..467
FT /note="WD 5"
FT REGION 38..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..65
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 21
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q13610"
FT MOD_RES 49
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q13610"
FT MOD_RES 54
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q13610"
FT MOD_RES 58
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q13610"
FT MOD_RES 85
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q13610"
FT MOD_RES 484
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q13610"
FT MOD_RES 493
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q99LL5"
SQ SEQUENCE 500 AA; 55865 MW; 55CF4CFE17F15DA3 CRC64;
MNRSRQVTCV AWVRCGVAKE TPDKVELSKE EVKRLIAEAK EKLQEEGGSD EQETGNPSED
GMQSARTQAR PREPLEDGDP EDDRTLDDDE LAEYDLDKYD EEGDPDAETL GESLLGLTVY
GSNDQDPYVT LKDTEQYERE DFLIKPSDNL IVCGRAEQDQ CNLEVHVYNQ EEDSFYVHHD
ILLSAYPLSV EWLNFDPSPD DSTGNYIAVG NMTPVIEVWD LDIVDSLEPV FTLGSKLSKK
KKKKGKKNSS ADGHTDAVLD LSWNKLVRNV LASASADNTV ILWDMSLGKP AASLAVHTDK
VQTLQFHPFE AQTLISGSYD KSVALYDCRS PEESHRMWRF SGQIERVTWN HFSPCHFLAS
TDDGFVYNLD ARSDKPIFTL NAHNDEISGL DLSSQIKGCL VTASADKYVK IWDILGDRPS
LVHSRDMKMG VLFCSSCCPD LPFIYAFGGQ KEGLRVWDIS TVSSVNEAFG RRERLVLGNA
RTSSISGPFG NRSSETPMES
