ID   PWP2_CAEEL              Reviewed;         910 AA.
AC   P91341;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2002, sequence version 2.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Periodic tryptophan protein 2 homolog;
GN   ORFNames=F55F8.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SIMILARITY: Belongs to the WD repeat PWP2 family. {ECO:0000305}.
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DR   EMBL; FO081477; CCD71885.1; -; Genomic_DNA.
DR   PIR; T29585; T29585.
DR   RefSeq; NP_491653.2; NM_059252.5.
DR   AlphaFoldDB; P91341; -.
DR   SMR; P91341; -.
DR   BioGRID; 37682; 9.
DR   STRING; 6239.F55F8.3; -.
DR   iPTMnet; P91341; -.
DR   EPD; P91341; -.
DR   PaxDb; P91341; -.
DR   PeptideAtlas; P91341; -.
DR   EnsemblMetazoa; F55F8.3.1; F55F8.3.1; WBGene00018891.
DR   GeneID; 172224; -.
DR   KEGG; cel:CELE_F55F8.3; -.
DR   UCSC; F55F8.3; c. elegans.
DR   CTD; 172224; -.
DR   WormBase; F55F8.3; CE30542; WBGene00018891; -.
DR   eggNOG; KOG0291; Eukaryota.
DR   GeneTree; ENSGT00550000074981; -.
DR   HOGENOM; CLU_010458_0_0_1; -.
DR   InParanoid; P91341; -.
DR   OMA; QSEQYIM; -.
DR   OrthoDB; 290630at2759; -.
DR   PhylomeDB; P91341; -.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:P91341; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00018891; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0034388; C:Pwp2p-containing subcomplex of 90S preribosome; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0000028; P:ribosomal small subunit assembly; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR027145; PWP2.
DR   InterPro; IPR011044; Quino_amine_DH_bsu.
DR   InterPro; IPR007148; SSU_processome_Utp12.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR19858; PTHR19858; 1.
DR   Pfam; PF04003; Utp12; 1.
DR   Pfam; PF00400; WD40; 4.
DR   SMART; SM00320; WD40; 12.
DR   SUPFAM; SSF50969; SSF50969; 1.
DR   SUPFAM; SSF50978; SSF50978; 2.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   3: Inferred from homology;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..910
FT                   /note="Periodic tryptophan protein 2 homolog"
FT                   /id="PRO_0000051174"
FT   REPEAT          12..50
FT                   /note="WD 1"
FT   REPEAT          53..92
FT                   /note="WD 2"
FT   REPEAT          94..134
FT                   /note="WD 3"
FT   REPEAT          144..183
FT                   /note="WD 4"
FT   REPEAT          188..227
FT                   /note="WD 5"
FT   REPEAT          271..310
FT                   /note="WD 6"
FT   REPEAT          313..355
FT                   /note="WD 7"
FT   REPEAT          358..397
FT                   /note="WD 8"
FT   REPEAT          400..439
FT                   /note="WD 9"
FT   REPEAT          443..485
FT                   /note="WD 10"
FT   REPEAT          486..523
FT                   /note="WD 11"
FT   REPEAT          525..563
FT                   /note="WD 12"
FT   REPEAT          586..625
FT                   /note="WD 13"
FT   REPEAT          688..728
FT                   /note="WD 14"
FT   REGION          867..910
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        877..910
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   910 AA;  102197 MW;  CC3C7DA636F131E1 CRC64;
     MDTNFKLSNC IGTVYRDGQV AFSKDGYSVI SPIGNKLSIF DLRNNTSKTL DIDCNYNIKR
     LSISPSGYHL LASDERGVVH FVHLLSEFKI YTFRSNKPIG SLQWSPDATR VAICRENDLQ
     IHEFGKSIEN KVYNPFSLSR TYKLSSDSLK TIDWSDDANL LVSGGEDRVV RVVGAKDFKN
     LFIHPLASHK GYIVNCQFMK NSYDMITVCK RGLANVWTCN LRPGELVEGI WKKDEEGSDD
     IEMLEDGEQK VEKIFFEKTK KYWLSESSGS GKSVDVTAAR FHKETNILAT AFNNGVIVLH
     EIPSFALVHN LRVSEMRIQT VAWNLTGDWL AIGCGKGSTA QLVVWEWQSE SYVMKQQAHS
     LRITTAEYSP DGSLMATGAE DGKVKIWNSR SSFCTVTFDE HTSGVTAVKW TQSGRAILSA
     SLDGTVRAHD LKRYRNFRTL VCPEPTQLAT LAVDKAGDLV IAGAKEVFNI YIWSFETGHL
     LDILSGHESA ISSIDIHGNH IVSGSWDRTI KMWTIVDSQA ETVEVSHEAL DVKFSPAGDE
     IAVLTSDGVI TFFEAKEMIN LGSIDTKLDT DPARGSRDTI TRQSAAKTKT FTRIRFSPDG
     NLLLAGGESN NFCLYSVPER MILKKWQITA NRSLDGVILD FNRRNFTEFG NMQLVDTSDE
     EDELEPNNKM SIKLPGTKNF DLGERRARPE VNIYEVTYCP TGRRFAICST EGVSVYSLDT
     ISMFDPFQLD SQTNAEVIKR AVWNNDYSTA IMASLRLNNA QYITECLEST SISQIPLVAS
     SLPLMYAERL LKWMVEGNVM SSTRHVHFYM IWLRAILQHH GMQLKGRADV ATLTGIQQIV
     AHHQQHITKL ANQNKFALNW LVKIRQSKKS VKKEEEEEED VSDESDDEDI EDESAGSDDE
     DSDDSVEIIE