PWP2_DICDI
ID PWP2_DICDI Reviewed; 922 AA.
AC Q54PE0;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 107.
DE RecName: Full=Periodic tryptophan protein 2 homolog;
GN Name=pwp2; Synonyms=utp1; ORFNames=DDB_G0284621;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat PWP2 family. {ECO:0000305}.
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DR EMBL; AAFI02000070; EAL65080.1; -; Genomic_DNA.
DR RefSeq; XP_638435.1; XM_633343.1.
DR AlphaFoldDB; Q54PE0; -.
DR SMR; Q54PE0; -.
DR STRING; 44689.DDB0235358; -.
DR PaxDb; Q54PE0; -.
DR PRIDE; Q54PE0; -.
DR EnsemblProtists; EAL65080; EAL65080; DDB_G0284621.
DR GeneID; 8624685; -.
DR KEGG; ddi:DDB_G0284621; -.
DR dictyBase; DDB_G0284621; pwp2.
DR eggNOG; KOG0291; Eukaryota.
DR HOGENOM; CLU_010458_0_0_1; -.
DR InParanoid; Q54PE0; -.
DR OMA; QSEQYIM; -.
DR PhylomeDB; Q54PE0; -.
DR Reactome; R-DDI-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:Q54PE0; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0005829; C:cytosol; ISS:dictyBase.
DR GO; GO:0005730; C:nucleolus; ISS:dictyBase.
DR GO; GO:0034388; C:Pwp2p-containing subcomplex of 90S preribosome; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000028; P:ribosomal small subunit assembly; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISS:dictyBase.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR027145; PWP2.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR007148; SSU_processome_Utp12.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19858; PTHR19858; 1.
DR Pfam; PF04003; Utp12; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 10.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF50998; SSF50998; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..922
FT /note="Periodic tryptophan protein 2 homolog"
FT /id="PRO_0000328418"
FT REPEAT 12..52
FT /note="WD 1"
FT REPEAT 53..92
FT /note="WD 2"
FT REPEAT 94..132
FT /note="WD 3"
FT REPEAT 141..180
FT /note="WD 4"
FT REPEAT 182..221
FT /note="WD 5"
FT REPEAT 271..310
FT /note="WD 6"
FT REPEAT 313..353
FT /note="WD 7"
FT REPEAT 356..395
FT /note="WD 8"
FT REPEAT 398..439
FT /note="WD 9"
FT REPEAT 443..485
FT /note="WD 10"
FT REPEAT 486..525
FT /note="WD 11"
FT REPEAT 528..567
FT /note="WD 12"
FT REPEAT 590..629
FT /note="WD 13"
FT REPEAT 691..731
FT /note="WD 14"
FT REGION 893..922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 922 AA; 104694 MW; 8918BB288FC7A0BF CRC64;
MKFGYKFSNL LGTVYNKGNI LFTPDGNTVI SPVGNRLTVF DLVNHTSITL PIQSKYNIRR
LALSPNGQIL ITSDESGHTL IINLTRQVVL GEYKFFKTPK SILFSPNGAI IAIAVLEKVF
LFKTPIIQKQ PNPLIRLSVF THKSAVISMC WSADSLKLMI GCKNGTLLIR QGKSERVSYF
QVKGSGIINC FFGNEESTIA YAVTPTGLAS WDYKTNEEME QEKLERVENG ETAYLREEEM
DEEKLKVITE NQRLYKGRWI FKGFKKFENY GVKCKVKTVC FHLKSKLLLV GFSTGQFILY
EMPGFNQLYK LNISSHGIST SAINNTGEWL AFGCSELGQL LVWEWRSETY ILKQQGHSYN
MNTVAYSPDG QTIATGGEDG KVKIWNTTSG YCYITFTEHE GPVTAVKYSP VSSQNVVFSA
GVDGTIRAFD LVRYRNFRTF VSPNKTQFSC LAVDPSGEII AAGSLDSFEI YVWSVRTGRL
TDILSGHQSP VCELAFDPIN PFLASASWDK SCKIWNIFED REIRESIQHT SDVLTCAYSQ
DGKKFIVSCL DGTIQIYETS TWGQIGLIDG KNDIMGGRGY KDEILAKNNS AGRAFTKIAF
TPNGECIIAG GNSKYICIYH IDQQVLIKKY STSSNLSLDG ITLDINWKRV GEFGHLDAME
KDFDSDDDLY QQNKEYLTGS SKGDLSKRTT KKKQKTTSIS VSPTGRAWAV STTEGLLIYS
LDDFLFFDPT DLSIDINPDS ILSELNLKNY LKSLIMSIKL NEKPIIEKVF ESIPFNEIQL
VCQEFPIYYL KNFIQFLSGY FEKNHHLEFQ MKWVKLISIY HGKYIKTNSL SMITSLRNLQ
KTITQTYNDI SKVCDDNIFS MEYFKTVLLK ELKSQEETNK ISKKSQKYKK YLESKKNKEQ
EEDQFSDDEE TVYQNNKKNK NK
