PWP2_NEUCR
ID PWP2_NEUCR Reviewed; 899 AA.
AC Q9C270; Q7RVU5;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=Periodic tryptophan protein 2 homolog;
GN ORFNames=B18D24.40, NCU03794;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- SIMILARITY: Belongs to the WD repeat PWP2 family. {ECO:0000305}.
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DR EMBL; AL513466; CAC28802.1; -; Genomic_DNA.
DR EMBL; CM002240; EAA31947.1; -; Genomic_DNA.
DR RefSeq; XP_961183.1; XM_956090.2.
DR AlphaFoldDB; Q9C270; -.
DR SMR; Q9C270; -.
DR STRING; 5141.EFNCRP00000003285; -.
DR EnsemblFungi; EAA31947; EAA31947; NCU03794.
DR GeneID; 3877368; -.
DR KEGG; ncr:NCU03794; -.
DR VEuPathDB; FungiDB:NCU03794; -.
DR HOGENOM; CLU_010458_0_0_1; -.
DR InParanoid; Q9C270; -.
DR OMA; QSEQYIM; -.
DR Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR GO; GO:0005737; C:cytoplasm; IEA:EnsemblFungi.
DR GO; GO:0034388; C:Pwp2p-containing subcomplex of 90S preribosome; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:EnsemblFungi.
DR GO; GO:0030010; P:establishment of cell polarity; IEA:EnsemblFungi.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000028; P:ribosomal small subunit assembly; IBA:GO_Central.
DR GO; GO:0000920; P:septum digestion after cytokinesis; IEA:EnsemblFungi.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR027145; PWP2.
DR InterPro; IPR007148; SSU_processome_Utp12.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19858; PTHR19858; 1.
DR Pfam; PF04003; Utp12; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 13.
DR SUPFAM; SSF50978; SSF50978; 3.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..899
FT /note="Periodic tryptophan protein 2 homolog"
FT /id="PRO_0000051177"
FT REPEAT 9..52
FT /note="WD 1"
FT REPEAT 53..92
FT /note="WD 2"
FT REPEAT 94..132
FT /note="WD 3"
FT REPEAT 149..188
FT /note="WD 4"
FT REPEAT 193..232
FT /note="WD 5"
FT REPEAT 252..291
FT /note="WD 6"
FT REPEAT 294..334
FT /note="WD 7"
FT REPEAT 337..376
FT /note="WD 8"
FT REPEAT 379..418
FT /note="WD 9"
FT REPEAT 422..464
FT /note="WD 10"
FT REPEAT 465..504
FT /note="WD 11"
FT REPEAT 507..546
FT /note="WD 12"
FT REPEAT 569..608
FT /note="WD 13"
FT REPEAT 669..709
FT /note="WD 14"
FT REGION 639..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 866..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..668
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 899 AA; 99704 MW; 797F5A24D6C05136 CRC64;
MKTDFKFSNL LGTVYCQGNL LFSPDGTHLF SPVGNRVTVF NLVDNKSYTL PFSHRKNIAR
IGLTPQGNLL LSIDEDGQAI LTNVPRRVVL YHFSFKAPVT ALSFSPSGRH FIVGLGRKIE
VWHVPSTPDA NADGELEFAP FVKHHTHVQH FDDVRHIEWS HDSRFFLTSS KDLTARIWSV
DQEEGFTPTV LSGHRQGVVG AWFSKDQETI YTVSKDGAVF DWQYVAKPGQ DEDMVDDDDL
AWRIVNKHYF MQNSATVRCA AFHPESNLLV AGFSNGIFGL YEMPDFNMIH TLSISQNEID
FVTINKSGEW LAFGASKLGQ LLVWEWQSES YILKQQGHFD SMNSLVYSPD GQRIVTVADD
GKIKVWDTES GFCIVTFTEH TSGITACEFS KKGNVLFTSS LDGSIRAWDL IRYRNFRTFT
APERLSFSCM AVDPSGEIVA AGSVDSFDIH IWSVQTGQLL DRLSGHEGPV SSLAFAPNGG
LLVSGSWDRT ARIWSIFNRT QTSEPLQLNS DVLDIAFRPD SLQIAISTLD GNLSFWSVSE
AEQQAGLDGR RDVSGGRKIG DRRTAANVAG TKAFNTIRYS TDGSCLLAGG NSKYICLYSV
TTMVLLKKYT VSVNLSIQGT QEFLNSKLLT EAGPQGLLDE QGEASDFEDR IDRSLPGSKR
GDPSARRKNP EVRVNGVAFS PNGSAFCAAS TEGLLIYSLD TTIQFDPFDL NMEITPTSTL
AVLEKEKDYL KALVMAFRLN EAGLIQRVFQ AIPYTDIPLV VEQFPNVYVA RLLRYVAAQT
EQSPHVEFCL LWIKALVDKH GAWLSANRGK VDVELRVVAR AVSKMRDEIR KLADENVYMV
DYLLGQASAA KETNTTKTLA LEWATTGSDE QPGAGGMSLN DVMQQDEGNA SEDEWIGLV
