ID   PWP2_PONAB              Reviewed;         918 AA.
AC   Q5RFQ3;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Periodic tryptophan protein 2 homolog;
GN   Name=PWP2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat PWP2 family. {ECO:0000305}.
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DR   EMBL; CR857099; CAH89404.1; -; mRNA.
DR   RefSeq; NP_001129000.1; NM_001135528.2.
DR   AlphaFoldDB; Q5RFQ3; -.
DR   SMR; Q5RFQ3; -.
DR   STRING; 9601.ENSPPYP00000012815; -.
DR   GeneID; 100190840; -.
DR   KEGG; pon:100190840; -.
DR   CTD; 5822; -.
DR   eggNOG; KOG0291; Eukaryota.
DR   InParanoid; Q5RFQ3; -.
DR   OrthoDB; 290630at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR027145; PWP2.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR007148; SSU_processome_Utp12.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   PANTHER; PTHR19858; PTHR19858; 1.
DR   Pfam; PF04003; Utp12; 1.
DR   Pfam; PF00400; WD40; 3.
DR   SMART; SM00320; WD40; 13.
DR   SUPFAM; SSF50998; SSF50998; 2.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE   2: Evidence at transcript level;
KW   Nucleus; Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..918
FT                   /note="Periodic tryptophan protein 2 homolog"
FT                   /id="PRO_0000281771"
FT   REPEAT          12..50
FT                   /note="WD 1"
FT   REPEAT          53..93
FT                   /note="WD 2"
FT   REPEAT          94..132
FT                   /note="WD 3"
FT   REPEAT          142..181
FT                   /note="WD 4"
FT   REPEAT          186..225
FT                   /note="WD 5"
FT   REPEAT          283..322
FT                   /note="WD 6"
FT   REPEAT          325..365
FT                   /note="WD 7"
FT   REPEAT          368..407
FT                   /note="WD 8"
FT   REPEAT          410..449
FT                   /note="WD 9"
FT   REPEAT          453..495
FT                   /note="WD 10"
FT   REPEAT          496..535
FT                   /note="WD 11"
FT   REPEAT          538..577
FT                   /note="WD 12"
FT   REPEAT          600..639
FT                   /note="WD 13"
FT   REPEAT          697..737
FT                   /note="WD 14"
FT   REGION          237..262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          878..918
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         895
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BU03"
FT   MOD_RES         899
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8BU03"
SQ   SEQUENCE   918 AA;  102286 MW;  BA2CE98FF6284EC1 CRC64;
     MKFAYRFSNL LGTVYRRGNL NFTCDGNSVI SPVGNRVTVF DLKNNKSDTL PLATRYNVKC
     VGLSPDGRLA IIVDEGGDAL LVSLVCRSVL HHFHFKGSVH SVSFSPDGRK FVVTKGNIAQ
     MYHAPGKKRE FNAFVLDKTY FGPYDETTCI DWTDDSRCFV VGSKDMSTWV FGAERWDNLI
     YYALGGHKDA IVACFFESNS LDLYSLSQDG VLCMWQCDTP PEGLRLKPPA GWKADLLQRE
     QEEEEEEGDR ETTIRGKATP AEEEKTGKVK YSRLAKYFFN KEGDFNNLTA AAFHKKSHLL
     VTGFASGIFH LHELPEFNLI HSLSISDQSI ASVAINSSGD WIAFGCSGLG QLLVWEWQSE
     SYVLKQQGHF NSMVALAYSP DGQYIVTGGD DGKVKVWNTL SGFCFVTFTE HSSGVTGVTF
     TATGYVVVTS SMDGTVRAFD LHRYRNFRTF TSPRPTQFSC VAVDASGEIV SAGAQDSFEI
     FVWSMQTGRL LDVLSGHEGP ISGLCFNPMK SILASASWDK TERLWDMFDS WRTKETLALT
     SDALAVTFRP DGAELAVATL NSQITFWDPE NAVQTGSIEG RHHLKTGRKE LDKITAKHAA
     KGKAFTTLCY SADGQSILAG GMSKFVCIYH VREQILMKRF EISCNLSLDA MEEFLNRRKM
     TEFGNLALID QDAGQEDGVA IPLPGVRKGD MSSRHFKPEI RVTSLRFSPT GRCWAATTTE
     GLLIFSLDTR VLFDPFELDT SITPGRVREA LRQQDFTRAI LMALRLNESK LVQEALEAVP
     SGEIEVVTSS LPELYVEKVL EFLASSFEVS RHLEFYLLWT HRLLMLHGQK LKSRAGTLLP
     VIQFLQKSIQ RHLDDLSKLC SWNRYNMQYA LAVSKQRGTK RSLDPLGSEE EAEASEDDSL
     HLLGGGGRDS EEGMLAES