PWP2_SCHPO
ID PWP2_SCHPO Reviewed; 854 AA.
AC Q9C1X1;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Periodic tryptophan protein 2 homolog;
GN ORFNames=SPBC713.04c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-640 AND SER-645, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- SIMILARITY: Belongs to the WD repeat PWP2 family. {ECO:0000305}.
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DR EMBL; CU329671; CAC22605.1; -; Genomic_DNA.
DR RefSeq; NP_595343.1; NM_001021251.2.
DR AlphaFoldDB; Q9C1X1; -.
DR SMR; Q9C1X1; -.
DR BioGRID; 277696; 3.
DR STRING; 4896.SPBC713.04c.1; -.
DR iPTMnet; Q9C1X1; -.
DR MaxQB; Q9C1X1; -.
DR PaxDb; Q9C1X1; -.
DR PRIDE; Q9C1X1; -.
DR EnsemblFungi; SPBC713.04c.1; SPBC713.04c.1:pep; SPBC713.04c.
DR GeneID; 2541182; -.
DR KEGG; spo:SPBC713.04c; -.
DR PomBase; SPBC713.04c; -.
DR VEuPathDB; FungiDB:SPBC713.04c; -.
DR eggNOG; KOG0291; Eukaryota.
DR HOGENOM; CLU_010458_0_0_1; -.
DR InParanoid; Q9C1X1; -.
DR OMA; QSEQYIM; -.
DR PhylomeDB; Q9C1X1; -.
DR Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:Q9C1X1; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR GO; GO:0034388; C:Pwp2p-containing subcomplex of 90S preribosome; IBA:GO_Central.
DR GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR GO; GO:0005732; C:sno(s)RNA-containing ribonucleoprotein complex; ISO:PomBase.
DR GO; GO:0030515; F:snoRNA binding; ISO:PomBase.
DR GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0000028; P:ribosomal small subunit assembly; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR027145; PWP2.
DR InterPro; IPR011044; Quino_amine_DH_bsu.
DR InterPro; IPR007148; SSU_processome_Utp12.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19858; PTHR19858; 1.
DR Pfam; PF04003; Utp12; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 12.
DR SUPFAM; SSF50969; SSF50969; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..854
FT /note="Periodic tryptophan protein 2 homolog"
FT /id="PRO_0000051178"
FT REPEAT 9..52
FT /note="WD 1"
FT REPEAT 53..93
FT /note="WD 2"
FT REPEAT 94..132
FT /note="WD 3"
FT REPEAT 144..183
FT /note="WD 4"
FT REPEAT 188..227
FT /note="WD 5"
FT REPEAT 252..291
FT /note="WD 6"
FT REPEAT 294..334
FT /note="WD 7"
FT REPEAT 337..376
FT /note="WD 8"
FT REPEAT 379..418
FT /note="WD 9"
FT REPEAT 422..464
FT /note="WD 10"
FT REPEAT 465..504
FT /note="WD 11"
FT REPEAT 507..546
FT /note="WD 12"
FT REPEAT 569..608
FT /note="WD 13"
FT REPEAT 668..709
FT /note="WD 14"
FT MOD_RES 640
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 645
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 854 AA; 95441 MW; 5B17871EC1C46566 CRC64;
MKTEFGFSNL VGTIFSKGNL VFTPDGFSIL SPVGNRVSVY NLKDNTSYTF PFENHKNISH
IALSPTSTLL LSVDEEGRCI LCNFLRRSVL HYFNFKSPVG AIEFSPNGKF FAVSLGKLIQ
VWRTPNSLEE REFAPFVLHR EYTGHFDDIV SISWSADSRF FISTSKDLTA RLHSVDPIEG
FHPCALTGHK NTVVSGFFSK DQQTIYTVSK DGALFVWKYS PLFQAGEVID EEAEENKTRT
HIWLIKERHY FNQNSKLRCA AFHPTSNLLV VGFSSGLFGI YELPSFTMLY QLSITQSNID
TLTVNSTGDW IAIGSSKLGQ LLVWEWQSES YVLKQQSHYD ALSTLQYSSD GQRIITGADD
GKIKVWDMNS GFCIVTFTQH TSAVSGLCFS KRGNVLFSSS LDGSVRAWDL IRYRNFRTFT
APSRVQFSCI AVDPSGEIVC AGSQDSFEIF MWSVQTGQLL ETLAGHEGPV SSLSFNSSGS
LLASGSWDKT VRIWDIFSRS GIVEPLPIPS DVLSLAFHPD GKEVCVASLD GQLTFWNVQE
GKQTSLIDGR KDLSGGRRFD DARTAENSSL NKTFTSICYS ADGSCVLSAG TSKYVCLYDI
ITGVLIKKFQ LSKNESLQGV QEMLNSRKMT EAGSIELIDT QGEESDLEDR IDRTLPGARR
GDLSARKTRP EIICHGVQFS PSGGAFAAAT TEGLMIYSLY NDFLFDPINL DMDITPSTTL
TMCAEGEFLI SLVMALRLNE YKVVQKVYES IPITDVEHVV QELPVSYLAN FMGYLSSFAA
ETPHIEFHLR WMKSVLTYHG EYLRRKNFEF ASQLTSLQKS IVVLSKRLSQ LSSNNEFQLS
FLLDKMHLRL ENTA
