ID   PWP3A_BOVIN             Reviewed;         641 AA.
AC   Q08DK9;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=PWWP domain-containing DNA repair factor 3A {ECO:0000305};
DE            Short=PWWP3A {ECO:0000305};
DE   AltName: Full=Mutated melanoma-associated antigen 1;
DE            Short=MUM-1;
DE   AltName: Full=PWWP domain-containing protein MUM1;
GN   Name=PWWP3A; Synonyms=MUM1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hippocampus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the DNA damage response pathway by contributing
CC       to the maintenance of chromatin architecture. Recruited to the vicinity
CC       of DNA breaks by TP53BP1 and plays an accessory role to facilitate
CC       damage-induced chromatin changes and promoting chromatin relaxation.
CC       Required for efficient DNA repair and cell survival following DNA
CC       damage (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with TP53BP1 (via BRCT domain); the interaction is
CC       not dependent on its phosphorylation status. Binds nucleosomes.
CC       Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3) (in
CC       vitro) (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Recruited to DNA
CC       damage sites via its interaction with the BRCT domain of TP53BP1.
CC       {ECO:0000250}.
CC   -!- DOMAIN: The PWWP domain mediates the interaction with nucleosomes.
CC   -!- SIMILARITY: Belongs to the PWWP3A family. {ECO:0000305}.
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DR   EMBL; BC123693; AAI23694.1; -; mRNA.
DR   RefSeq; NP_001069090.1; NM_001075622.1.
DR   RefSeq; XP_005209345.1; XM_005209288.1.
DR   RefSeq; XP_005209346.1; XM_005209289.3.
DR   AlphaFoldDB; Q08DK9; -.
DR   SMR; Q08DK9; -.
DR   STRING; 9913.ENSBTAP00000009840; -.
DR   PaxDb; Q08DK9; -.
DR   PRIDE; Q08DK9; -.
DR   Ensembl; ENSBTAT00000009840; ENSBTAP00000009840; ENSBTAG00000030839.
DR   GeneID; 513471; -.
DR   KEGG; bta:513471; -.
DR   CTD; 84939; -.
DR   VEuPathDB; HostDB:ENSBTAG00000030839; -.
DR   VGNC; VGNC:57909; PWWP3A.
DR   eggNOG; ENOG502QPRU; Eukaryota.
DR   GeneTree; ENSGT00390000001700; -.
DR   HOGENOM; CLU_388271_0_0_1; -.
DR   InParanoid; Q08DK9; -.
DR   OMA; AGMLVWC; -.
DR   OrthoDB; 339225at2759; -.
DR   TreeFam; TF328774; -.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000030839; Expressed in spermatid and 106 other tissues.
DR   ExpressionAtlas; Q08DK9; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0031491; F:nucleosome binding; ISS:UniProtKB.
DR   GO; GO:0006325; P:chromatin organization; ISS:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; ISS:UniProtKB.
DR   CDD; cd06080; MUM1_like; 1.
DR   InterPro; IPR033368; MUM1.
DR   InterPro; IPR035504; MUM1-like_PWWP.
DR   InterPro; IPR040263; PWP3A/B.
DR   PANTHER; PTHR31333; PTHR31333; 2.
DR   PANTHER; PTHR31333:SF4; PTHR31333:SF4; 2.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA repair; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..641
FT                   /note="PWWP domain-containing DNA repair factor 3A"
FT                   /id="PRO_0000295045"
FT   DOMAIN          343..404
FT                   /note="PWWP"
FT   REGION          98..329
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          463..486
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..129
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..178
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         156
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:B1H224"
FT   MOD_RES         307
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6DID5"
SQ   SEQUENCE   641 AA;  71109 MW;  C00733E698EFB692 CRC64;
     MTDAKYVLCR WKKRLWPAKV LAGTEKSAKN KRKKGYFLNV QILSLDKKIK VKSAEAKVLR
     KVHIEDIASS LASQDGTPAA PLEELTYRRS LRVALDVLNE RQGSSSREGT TPRPPRVKPM
     EPASWPPKPS LSPSFLEDTA GSPGPTRRER MSQRLSGLPA GEEDLEYGVD HKEGLKRSGG
     LDAPAMCSAS GGAQDREASR KQQADWMTPL GKQGRNPAQG PHSGQRVAPS SEGAGQEDGE
     TGAGPAALCS PPGGRDLSPL DGCPAEHLGL DSGQRPRAHM SPHSPAQLGP AEEAADTRPL
     EEARPLSEEF MEPSAVNSLL EEDEDDEEPP RILLYHEPRS FEVGMLVWHK YQKYPFWPAV
     VKSVRRRDKK ASVLFIEGNM NPRGRGISVL LRRLKHFDCK EKQALLDEAK EDFAQAIGWC
     VSLITDYRVR LGCGSFAGSF LEYYAADISS PVRKSIQQDV QGTRFPQLSG GDPEEPVAGS
     PQGRRPAYRK VLPDRSRAAR DRANQKLVEY IVKARGAESH LRAILRNRKP SRWLKTFLSS
     GQYMTCVETY LEDEEQLDLV VKYLQGVYKQ AGCQLLARGH GDGIRFILDV LLPEAIICAI
     SAVDAVDYKT AEEKYIRGPA LSSREKEIFD NQLLEERNRR C