PWP3B_MOUSE
ID PWP3B_MOUSE Reviewed; 681 AA.
AC Q4VA55; B1AW67; Q0VBL8; Q7TSI2; Q8BS63;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=PWWP domain-containing DNA repair factor 3B {ECO:0000305};
DE Short=PWWP3B {ECO:0000305};
DE AltName: Full=Mutated melanoma-associated antigen 1-like protein 1;
DE Short=MUM1-like protein 1;
DE AltName: Full=PWWP domain-containing protein MUM1L1;
GN Name=Pwwp3b; Synonyms=Mum1l1 {ECO:0000312|MGI:MGI:2445062};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 91-681.
RC STRAIN=C57BL/6J; TISSUE=Embryonic breast;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-128, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the PWWP3A family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC28940.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL732419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC053077; AAH53077.1; -; mRNA.
DR EMBL; BC068178; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC096534; AAH96534.1; -; mRNA.
DR EMBL; BC120584; AAI20585.1; -; mRNA.
DR EMBL; AK035086; BAC28940.1; ALT_INIT; mRNA.
DR CCDS; CCDS30432.2; -.
DR RefSeq; NP_001158102.1; NM_001164630.1.
DR RefSeq; NP_001158103.1; NM_001164631.1.
DR RefSeq; NP_001158104.1; NM_001164632.1.
DR RefSeq; NP_001158105.1; NM_001164633.1.
DR RefSeq; NP_780750.2; NM_175541.3.
DR RefSeq; XP_006528604.1; XM_006528541.1.
DR RefSeq; XP_006528606.1; XM_006528543.1.
DR RefSeq; XP_006528607.1; XM_006528544.1.
DR RefSeq; XP_017173988.1; XM_017318499.1.
DR AlphaFoldDB; Q4VA55; -.
DR SMR; Q4VA55; -.
DR STRING; 10090.ENSMUSP00000108666; -.
DR iPTMnet; Q4VA55; -.
DR PhosphoSitePlus; Q4VA55; -.
DR MaxQB; Q4VA55; -.
DR PaxDb; Q4VA55; -.
DR PRIDE; Q4VA55; -.
DR ProteomicsDB; 291460; -.
DR Antibodypedia; 427; 87 antibodies from 20 providers.
DR Ensembl; ENSMUST00000113041; ENSMUSP00000108664; ENSMUSG00000042515.
DR Ensembl; ENSMUST00000113042; ENSMUSP00000108665; ENSMUSG00000042515.
DR Ensembl; ENSMUST00000113043; ENSMUSP00000108666; ENSMUSG00000042515.
DR Ensembl; ENSMUST00000113045; ENSMUSP00000108668; ENSMUSG00000042515.
DR GeneID; 245631; -.
DR KEGG; mmu:245631; -.
DR UCSC; uc009ukc.2; mouse.
DR CTD; 139221; -.
DR MGI; MGI:2445062; Pwwp3b.
DR VEuPathDB; HostDB:ENSMUSG00000042515; -.
DR eggNOG; ENOG502QPRU; Eukaryota.
DR GeneTree; ENSGT00390000001700; -.
DR HOGENOM; CLU_388271_0_0_1; -.
DR InParanoid; Q4VA55; -.
DR OMA; KYRKHEG; -.
DR OrthoDB; 339225at2759; -.
DR PhylomeDB; Q4VA55; -.
DR TreeFam; TF328774; -.
DR BioGRID-ORCS; 245631; 2 hits in 74 CRISPR screens.
DR ChiTaRS; Pwwp3b; mouse.
DR PRO; PR:Q4VA55; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q4VA55; protein.
DR Bgee; ENSMUSG00000042515; Expressed in 1st arch mandibular component and 181 other tissues.
DR ExpressionAtlas; Q4VA55; baseline and differential.
DR Genevisible; Q4VA55; MM.
DR CDD; cd06080; MUM1_like; 1.
DR InterPro; IPR035504; MUM1-like_PWWP.
DR InterPro; IPR040263; PWP3A/B.
DR PANTHER; PTHR31333; PTHR31333; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..681
FT /note="PWWP domain-containing DNA repair factor 3B"
FT /id="PRO_0000257833"
FT DOMAIN 377..438
FT /note="PWWP"
FT REGION 102..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 285..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..140
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 128
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 85
FT /note="A -> S (in Ref. 2; AAH96534)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 681 AA; 76989 MW; 9C9CC4524E3C68E1 CRC64;
MDGKYVLCNW KDQLWPAKVL DRSESPSESK RKNTSSLEVE ILSLDEKITV ESTDTKVLSK
SAVEAIMSSL AVQSEVIIAP REETAYERSL KMALEMVKEG TNLSQESMSE EQPTATASEN
VPEQPPDSPP HKKFRKLESN TQEDSASILL CSESDDSMTD DKLQVHTTGE SMPSEMDTKA
TENLGCCQTD PSLADEDDKK EEKKKIDISA IMSVNLSLKE ESEYIKEEKF VPSSEDLTVP
KEESQDILPE APLAVSSECS IVSENNMEDP GEGPSNQNLV SYANQNQSSV ESDVGAETST
AGCSGDFQVS LPTRDTVSSD LLLQRLDLED LEEEARASGK LLSLNPASAA ALENDNEDDD
EDLPRFILHY ETRAFETGMI VWFKYQKYPF WPAVIKSIRR KERKASVLLV EADMSPQKKG
VRVSLRRLKK YDCKEKQALV EKAREEYRES IDWCVSLICD YRVRLGCGSF TGSFFEYYAA
DISYPVRKII KQDTFRNIFP KLYNENVGEQ LPMASQAKRV SFQKILPDRM KPARDRANKN
LVDFIVNAKG TEDHLLGILK GTKKSKWLKS FLNAKSFTPC IETYFEDEDQ LDEVVKYLQE
IYKQIDQKML TLIKDDKIKF VLEVLLPEAI ICSISAVDGL DYEAAEAKYL KGPSLGCRER
ELYDSKILFE KRRRSLPNEG H
