ID   PX11A_BOVIN             Reviewed;         247 AA.
AC   Q0VCP2;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Peroxisomal membrane protein 11A;
DE   AltName: Full=Peroxin-11A;
DE   AltName: Full=Peroxisomal biogenesis factor 11A;
GN   Name=PEX11A;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in peroxisomal proliferation and may regulate
CC       peroxisomes division. May mediate binding of coatomer proteins to the
CC       peroxisomal membrane. Promotes membrane protrusion and elongation on
CC       the peroxisomal surface. {ECO:0000250|UniProtKB:O70597,
CC       ECO:0000250|UniProtKB:O75192}.
CC   -!- SUBUNIT: Homodimer. Heterodimer with PEX11G. Probably interacts with
CC       COPB2 and COPA. Interacts with PEX19. Interacts with FIS1.
CC       {ECO:0000250|UniProtKB:O70597, ECO:0000250|UniProtKB:O75192}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane
CC       {ECO:0000250|UniProtKB:O75192}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:O75192}.
CC   -!- SIMILARITY: Belongs to the peroxin-11 family. {ECO:0000305}.
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DR   EMBL; BC120076; AAI20077.1; -; mRNA.
DR   RefSeq; NP_001069189.1; NM_001075721.1.
DR   RefSeq; XP_010815258.1; XM_010816956.2.
DR   RefSeq; XP_015314667.1; XM_015459181.1.
DR   AlphaFoldDB; Q0VCP2; -.
DR   SMR; Q0VCP2; -.
DR   STRING; 9913.ENSBTAP00000008078; -.
DR   PaxDb; Q0VCP2; -.
DR   Ensembl; ENSBTAT00000008078; ENSBTAP00000008078; ENSBTAG00000006140.
DR   GeneID; 515608; -.
DR   KEGG; bta:515608; -.
DR   CTD; 8800; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006140; -.
DR   eggNOG; KOG4186; Eukaryota.
DR   GeneTree; ENSGT00390000014273; -.
DR   HOGENOM; CLU_049216_2_0_1; -.
DR   InParanoid; Q0VCP2; -.
DR   OMA; AAKRTMQ; -.
DR   OrthoDB; 1394894at2759; -.
DR   TreeFam; TF325704; -.
DR   Proteomes; UP000009136; Chromosome 21.
DR   Bgee; ENSBTAG00000006140; Expressed in conceptus and 105 other tissues.
DR   GO; GO:0005779; C:integral component of peroxisomal membrane; IEA:InterPro.
DR   GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central.
DR   GO; GO:0016559; P:peroxisome fission; IBA:GO_Central.
DR   GO; GO:0044375; P:regulation of peroxisome size; IBA:GO_Central.
DR   InterPro; IPR008733; PEX11.
DR   Pfam; PF05648; PEX11; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Peroxisome; Peroxisome biogenesis; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..247
FT                   /note="Peroxisomal membrane protein 11A"
FT                   /id="PRO_0000330307"
FT   TOPO_DOM        1..83
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        106..219
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        220..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        240..247
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          220..239
FT                   /note="Required for homodimerization, interaction with
FT                   PEX11G, and peroxisomal localization"
FT                   /evidence="ECO:0000250|UniProtKB:O75192"
SQ   SEQUENCE   247 AA;  28297 MW;  A4135FCB176B6AB2 CRC64;
     MDAFIRFTNQ TQGRDRLFRA TQYTCMLLRY LLEPKADNEK VVMKLKKLES SVSTGRKWFR
     LGNVVHALQA TQQSVRATDL VPRICLTLAS LNRVIYFICD TVLFVRSTGL ASGVNKEKWR
     RWAARYYYYS LLLSLVRDLY EVSLQMKQVA HDRAKREKSP SQDTLGYSVA DEETEWLQSL
     LLLLFHSLKR HPPLFLDTVK NFCDILNPLD QLGIYKSNPG IIGLGGLVSS VAGIITVAYP
     QMKLKTQ