PX11C_HUMAN
ID PX11C_HUMAN Reviewed; 241 AA.
AC Q96HA9; Q8NDM0;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Peroxisomal membrane protein 11C;
DE AltName: Full=Peroxin-11C;
DE AltName: Full=Peroxisomal biogenesis factor 11C;
DE AltName: Full=Protein PEX11 homolog gamma;
DE Short=PEX11-gamma;
GN Name=PEX11G; Synonyms=PEX11C;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, AND TOPOLOGY.
RX PubMed=12559946; DOI=10.1016/s0006-291x(02)02936-4;
RA Tanaka A., Okumoto K., Fujiki Y.;
RT "cDNA cloning and characterization of the third isoform of human peroxin
RT Pex11p.";
RL Biochem. Biophys. Res. Commun. 300:819-823(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION, AND TOPOLOGY.
RX PubMed=12417726; DOI=10.1128/mcb.22.23.8226-8240.2002;
RA Li X., Baumgart E., Dong G.-X., Morrell J.C., Jimenez-Sanchez G., Valle D.,
RA Smith K.D., Gould S.J.;
RT "PEX11alpha is required for peroxisome proliferation in response to 4-
RT phenylbutyrate but is dispensable for peroxisome proliferator-activated
RT receptor alpha-mediated peroxisome proliferation.";
RL Mol. Cell. Biol. 22:8226-8240(2002).
RN [5]
RP FUNCTION, SUBUNIT, INTERACTION WITH FIS1; PEX11A AND PEX11B, AND
RP SUBCELLULAR LOCATION.
RX PubMed=20826455; DOI=10.1242/jcs.064907;
RA Koch J., Pranjic K., Huber A., Ellinger A., Hartig A., Kragler F.,
RA Brocard C.;
RT "PEX11 family members are membrane elongation factors that coordinate
RT peroxisome proliferation and maintenance.";
RL J. Cell Sci. 123:3389-3400(2010).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: Promotes membrane protrusion and elongation on the
CC peroxisomal surface. {ECO:0000269|PubMed:20826455}.
CC -!- SUBUNIT: Homodimer. Heterodimer with either PEX11A or PEX11B. Interacts
CC with FIS1. {ECO:0000269|PubMed:20826455}.
CC -!- INTERACTION:
CC Q96HA9; Q13520: AQP6; NbExp=3; IntAct=EBI-17284886, EBI-13059134;
CC Q96HA9; Q9Y282: ERGIC3; NbExp=3; IntAct=EBI-17284886, EBI-781551;
CC Q96HA9; P48051: KCNJ6; NbExp=3; IntAct=EBI-17284886, EBI-12017638;
CC Q96HA9; Q9NUH8: TMEM14B; NbExp=3; IntAct=EBI-17284886, EBI-8638294;
CC Q96HA9; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-17284886, EBI-2548832;
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:12417726,
CC ECO:0000269|PubMed:12559946, ECO:0000269|PubMed:20826455}; Multi-pass
CC membrane protein {ECO:0000269|PubMed:12417726,
CC ECO:0000269|PubMed:12559946}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96HA9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96HA9-2; Sequence=VSP_013539;
CC -!- SIMILARITY: Belongs to the peroxin-11 family. {ECO:0000305}.
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DR EMBL; AB095921; BAD01558.1; -; mRNA.
DR EMBL; AL833945; CAD38800.1; -; mRNA.
DR EMBL; BC008780; AAH08780.1; -; mRNA.
DR CCDS; CCDS12178.1; -. [Q96HA9-1]
DR CCDS; CCDS77227.1; -. [Q96HA9-2]
DR RefSeq; NP_001257468.1; NM_001270539.1.
DR RefSeq; NP_001287810.1; NM_001300881.1. [Q96HA9-2]
DR RefSeq; NP_542393.1; NM_080662.3. [Q96HA9-1]
DR RefSeq; XP_011526730.1; XM_011528428.1. [Q96HA9-2]
DR RefSeq; XP_011526731.1; XM_011528429.2. [Q96HA9-2]
DR RefSeq; XP_011526733.1; XM_011528431.2. [Q96HA9-2]
DR AlphaFoldDB; Q96HA9; -.
DR BioGRID; 124990; 15.
DR IntAct; Q96HA9; 9.
DR STRING; 9606.ENSP00000221480; -.
DR iPTMnet; Q96HA9; -.
DR PhosphoSitePlus; Q96HA9; -.
DR BioMuta; PEX11G; -.
DR DMDM; 62901102; -.
DR EPD; Q96HA9; -.
DR jPOST; Q96HA9; -.
DR MassIVE; Q96HA9; -.
DR MaxQB; Q96HA9; -.
DR PaxDb; Q96HA9; -.
DR PeptideAtlas; Q96HA9; -.
DR PRIDE; Q96HA9; -.
DR ProteomicsDB; 76726; -. [Q96HA9-1]
DR ProteomicsDB; 76727; -. [Q96HA9-2]
DR TopDownProteomics; Q96HA9-1; -. [Q96HA9-1]
DR Antibodypedia; 42625; 66 antibodies from 22 providers.
DR DNASU; 92960; -.
DR Ensembl; ENST00000221480.6; ENSP00000221480.1; ENSG00000104883.8. [Q96HA9-1]
DR Ensembl; ENST00000593942.5; ENSP00000472216.1; ENSG00000104883.8. [Q96HA9-2]
DR GeneID; 92960; -.
DR KEGG; hsa:92960; -.
DR MANE-Select; ENST00000221480.6; ENSP00000221480.1; NM_080662.4; NP_542393.1.
DR UCSC; uc002mgk.3; human. [Q96HA9-1]
DR CTD; 92960; -.
DR GeneCards; PEX11G; -.
DR HGNC; HGNC:20208; PEX11G.
DR HPA; ENSG00000104883; Tissue enhanced (liver, testis).
DR MIM; 607583; gene.
DR neXtProt; NX_Q96HA9; -.
DR OpenTargets; ENSG00000104883; -.
DR PharmGKB; PA134987796; -.
DR VEuPathDB; HostDB:ENSG00000104883; -.
DR eggNOG; KOG4186; Eukaryota.
DR GeneTree; ENSGT00390000000427; -.
DR HOGENOM; CLU_100620_0_0_1; -.
DR InParanoid; Q96HA9; -.
DR OMA; CDIIDSY; -.
DR OrthoDB; 1522222at2759; -.
DR PhylomeDB; Q96HA9; -.
DR TreeFam; TF316770; -.
DR PathwayCommons; Q96HA9; -.
DR SignaLink; Q96HA9; -.
DR BioGRID-ORCS; 92960; 15 hits in 1069 CRISPR screens.
DR GenomeRNAi; 92960; -.
DR Pharos; Q96HA9; Tbio.
DR PRO; PR:Q96HA9; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96HA9; protein.
DR Bgee; ENSG00000104883; Expressed in right testis and 140 other tissues.
DR ExpressionAtlas; Q96HA9; baseline and differential.
DR Genevisible; Q96HA9; HS.
DR GO; GO:0005779; C:integral component of peroxisomal membrane; IEA:InterPro.
DR GO; GO:0031231; C:intrinsic component of peroxisomal membrane; IDA:UniProtKB.
DR GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central.
DR GO; GO:0005777; C:peroxisome; IDA:UniProtKB.
DR GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR GO; GO:0016559; P:peroxisome fission; IDA:UniProtKB.
DR GO; GO:0044375; P:regulation of peroxisome size; IDA:UniProtKB.
DR InterPro; IPR008733; PEX11.
DR InterPro; IPR026510; PEX11C_met.
DR PANTHER; PTHR20990; PTHR20990; 1.
DR Pfam; PF05648; PEX11; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Peroxisome; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..241
FT /note="Peroxisomal membrane protein 11C"
FT /id="PRO_0000105970"
FT TOPO_DOM 1..124
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..211
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 228..241
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..70
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_013539"
FT VARIANT 91
FT /note="C -> W (in dbSNP:rs2303146)"
FT /id="VAR_024560"
SQ SEQUENCE 241 AA; 26636 MW; E8B64A196C105913 CRC64;
MASLSGLASA LESYRGRDRL IRVLGYCCQL VGGVLVEQCP ARSEVGTRLL VVSTQLSHCR
TILRLFDDLA MFVYTKQYGL GAQEEDAFVR CVSVLGNLAD QLYYPCEHVA WAADARVLHV
DSSRWWTLST TLWALSLLLG VARSLWMLLK LRQRLRSPTA PFTSPLPRGK RRAMEAQMQS
EALSLLSNLA DLANAVHWLP RGVLWAGRFP PWLVGLMGTI SSILSMYQAA RAGGQAEATT
P
