PX11C_MOUSE
ID PX11C_MOUSE Reviewed; 241 AA.
AC Q6P6M5; Q9D8P0; Q9D8X4;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Peroxisomal membrane protein 11C;
DE AltName: Full=Peroxin-11C;
DE AltName: Full=Peroxisomal biogenesis factor 11C;
DE AltName: Full=Protein PEX11 homolog gamma;
DE Short=PEX11-gamma;
GN Name=Pex11g; Synonyms=Pex11c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=12417726; DOI=10.1128/mcb.22.23.8226-8240.2002;
RA Li X., Baumgart E., Dong G.-X., Morrell J.C., Jimenez-Sanchez G., Valle D.,
RA Smith K.D., Gould S.J.;
RT "PEX11alpha is required for peroxisome proliferation in response to 4-
RT phenylbutyrate but is dispensable for peroxisome proliferator-activated
RT receptor alpha-mediated peroxisome proliferation.";
RL Mol. Cell. Biol. 22:8226-8240(2002).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Kidney, Liver, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Promotes membrane protrusion and elongation on the
CC peroxisomal surface. {ECO:0000250|UniProtKB:Q96HA9}.
CC -!- SUBUNIT: Homodimer. Heterodimer with either PEX11A or PEX11B. Interacts
CC with FIS1. {ECO:0000250|UniProtKB:Q96HA9}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane
CC {ECO:0000250|UniProtKB:Q96HA9}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:Q96HA9}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6P6M5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P6M5-2; Sequence=VSP_013540, VSP_013541;
CC -!- TISSUE SPECIFICITY: Expressed in liver and at much lower levels in
CC heart, kidney and testis. {ECO:0000269|PubMed:12417726}.
CC -!- SIMILARITY: Belongs to the peroxin-11 family. {ECO:0000305}.
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DR EMBL; AK007582; BAB25120.1; -; mRNA.
DR EMBL; AK007848; BAB25302.1; -; mRNA.
DR EMBL; BC062135; AAH62135.1; -; mRNA.
DR CCDS; CCDS22061.1; -. [Q6P6M5-1]
DR CCDS; CCDS90364.1; -. [Q6P6M5-2]
DR RefSeq; NP_081227.1; NM_026951.2. [Q6P6M5-1]
DR AlphaFoldDB; Q6P6M5; -.
DR BioGRID; 213246; 1.
DR STRING; 10090.ENSMUSP00000004686; -.
DR iPTMnet; Q6P6M5; -.
DR PhosphoSitePlus; Q6P6M5; -.
DR SwissPalm; Q6P6M5; -.
DR EPD; Q6P6M5; -.
DR jPOST; Q6P6M5; -.
DR MaxQB; Q6P6M5; -.
DR PaxDb; Q6P6M5; -.
DR PeptideAtlas; Q6P6M5; -.
DR PRIDE; Q6P6M5; -.
DR ProteomicsDB; 301836; -. [Q6P6M5-1]
DR ProteomicsDB; 301837; -. [Q6P6M5-2]
DR Antibodypedia; 42625; 66 antibodies from 22 providers.
DR DNASU; 69129; -.
DR Ensembl; ENSMUST00000004686; ENSMUSP00000004686; ENSMUSG00000069633. [Q6P6M5-1]
DR Ensembl; ENSMUST00000111081; ENSMUSP00000106710; ENSMUSG00000069633. [Q6P6M5-2]
DR GeneID; 69129; -.
DR KEGG; mmu:69129; -.
DR UCSC; uc009krl.1; mouse. [Q6P6M5-2]
DR UCSC; uc009krm.1; mouse. [Q6P6M5-1]
DR CTD; 92960; -.
DR MGI; MGI:1920905; Pex11g.
DR VEuPathDB; HostDB:ENSMUSG00000069633; -.
DR eggNOG; KOG4186; Eukaryota.
DR GeneTree; ENSGT00390000000427; -.
DR HOGENOM; CLU_100620_0_0_1; -.
DR InParanoid; Q6P6M5; -.
DR OMA; CDIIDSY; -.
DR OrthoDB; 1522222at2759; -.
DR PhylomeDB; Q6P6M5; -.
DR TreeFam; TF316770; -.
DR BioGRID-ORCS; 69129; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Pex11g; mouse.
DR PRO; PR:Q6P6M5; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; Q6P6M5; protein.
DR Bgee; ENSMUSG00000069633; Expressed in spermatocyte and 137 other tissues.
DR Genevisible; Q6P6M5; MM.
DR GO; GO:0005779; C:integral component of peroxisomal membrane; IEA:InterPro.
DR GO; GO:0031231; C:intrinsic component of peroxisomal membrane; ISO:MGI.
DR GO; GO:0005778; C:peroxisomal membrane; IBA:GO_Central.
DR GO; GO:0005777; C:peroxisome; ISO:MGI.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR GO; GO:0016559; P:peroxisome fission; ISO:MGI.
DR GO; GO:0044375; P:regulation of peroxisome size; ISO:MGI.
DR InterPro; IPR008733; PEX11.
DR InterPro; IPR026510; PEX11C_met.
DR PANTHER; PTHR20990; PTHR20990; 1.
DR Pfam; PF05648; PEX11; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Membrane; Peroxisome; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..241
FT /note="Peroxisomal membrane protein 11C"
FT /id="PRO_0000105971"
FT TOPO_DOM 1..122
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 123..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..211
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..227
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 228..241
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VAR_SEQ 21..83
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_013540"
FT VAR_SEQ 214..241
FT /note="VGLMGTISSILSTCQAVRAGRQAEADSP -> KKTYLCMYLTHAWCLWRLGP
FT LELELT (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_013541"
FT CONFLICT 119
FT /note="R -> W (in Ref. 2; AAH62135)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 241 AA; 27152 MW; D2F2DE7E90BBD37C CRC64;
MALLNRLASA LESHRVRDRL IRTLGYCCQL IGGVLVEQCP NRSEVGRRLL VVSAQFNHCR
TVLRLFDDLA MFVYTKQYGL GTKEEDIFIR WLSVLSNVTD QLYYPCEHIA WAADAKVLRV
DSAWWWTLNT ALWTLSLLLG AVKALWTMLK LRQKLRSPTG TSASQLPRSK RRAMEARICS
EVLTLLSNLA DLANAVHWLP RGVLWAGRFP PWLVGLMGTI SSILSTCQAV RAGRQAEADS
P
