PXDC1_MOUSE
ID PXDC1_MOUSE Reviewed; 231 AA.
AC Q8JZU6; A0PJ93; Q9DBE6;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=PX domain-containing protein 1;
GN Name=Pxdc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=C57BL/6J; TISSUE=Liver;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 23-231 (ISOFORM 1).
RC STRAIN=129, and FVB/N; TISSUE=Liver, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8JZU6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8JZU6-2; Sequence=VSP_027286;
CC Name=3;
CC IsoId=Q8JZU6-3; Sequence=VSP_027284, VSP_027285;
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DR EMBL; AK005003; BAB23737.1; -; mRNA.
DR EMBL; AC124687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC018520; AAH18520.1; -; mRNA.
DR EMBL; BC037079; AAH37079.1; -; mRNA.
DR CCDS; CCDS36632.1; -. [Q8JZU6-1]
DR RefSeq; NP_080107.3; NM_025831.3. [Q8JZU6-1]
DR AlphaFoldDB; Q8JZU6; -.
DR SMR; Q8JZU6; -.
DR BioGRID; 211794; 14.
DR IntAct; Q8JZU6; 14.
DR STRING; 10090.ENSMUSP00000051246; -.
DR iPTMnet; Q8JZU6; -.
DR PhosphoSitePlus; Q8JZU6; -.
DR MaxQB; Q8JZU6; -.
DR PaxDb; Q8JZU6; -.
DR PRIDE; Q8JZU6; -.
DR ProteomicsDB; 301838; -. [Q8JZU6-1]
DR ProteomicsDB; 301839; -. [Q8JZU6-2]
DR ProteomicsDB; 301840; -. [Q8JZU6-3]
DR Antibodypedia; 2913; 40 antibodies from 8 providers.
DR DNASU; 66895; -.
DR Ensembl; ENSMUST00000021847; ENSMUSP00000021847; ENSMUSG00000021411. [Q8JZU6-2]
DR Ensembl; ENSMUST00000053459; ENSMUSP00000051246; ENSMUSG00000021411. [Q8JZU6-1]
DR GeneID; 66895; -.
DR KEGG; mmu:66895; -.
DR UCSC; uc007qbi.1; mouse. [Q8JZU6-1]
DR CTD; 221749; -.
DR MGI; MGI:1914145; Pxdc1.
DR VEuPathDB; HostDB:ENSMUSG00000021411; -.
DR eggNOG; ENOG502QQ4P; Eukaryota.
DR GeneTree; ENSGT00390000009209; -.
DR HOGENOM; CLU_1199438_0_0_1; -.
DR InParanoid; Q8JZU6; -.
DR OMA; YLHRSYA; -.
DR OrthoDB; 1192509at2759; -.
DR PhylomeDB; Q8JZU6; -.
DR TreeFam; TF331154; -.
DR BioGRID-ORCS; 66895; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q8JZU6; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q8JZU6; protein.
DR Bgee; ENSMUSG00000021411; Expressed in left lobe of liver and 160 other tissues.
DR ExpressionAtlas; Q8JZU6; baseline and differential.
DR Genevisible; Q8JZU6; MM.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR Gene3D; 3.30.1520.10; -; 1.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR040288; PXDC1.
DR PANTHER; PTHR31433; PTHR31433; 1.
DR SUPFAM; SSF64268; SSF64268; 1.
DR PROSITE; PS50195; PX; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..231
FT /note="PX domain-containing protein 1"
FT /id="PRO_0000297574"
FT DOMAIN 1..134
FT /note="PX"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00147"
FT VAR_SEQ 1..102
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027284"
FT VAR_SEQ 103..116
FT /note="VEKLLETVISMPCK -> MRSRSCWRRSSACR (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027285"
FT VAR_SEQ 157..231
FT /note="IMRSNGFCLANTETIVIDHSIPNGKDQLLDADSTEHLFENGGEFTSELEDGD
FT DPEAYVTNLSYYHLVPFETDILD -> AKEGTGALRTGVVDGCEPPGGCWELSVGLLEE
FT HQVFLTAERIFSPRKAFLRNHEVQWILFGKHRDHSH (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027286"
SQ SEQUENCE 231 AA; 26448 MW; 779ADA202634ECCB CRC64;
MASAVFEGTS LVNMFVRGCW VNGIRRLIVS RRGDEEEFFE IRTEWSDRSV LYLHRSFADL
GRLCKRLRDA FPEDRSELAR TPLRQGLLAI KGAHDIETRL NEVEKLLETV ISMPCKYSRS
EVVLTFFERS PLDQVLKNDN VHKIQPSFQS PVKISEIMRS NGFCLANTET IVIDHSIPNG
KDQLLDADST EHLFENGGEF TSELEDGDDP EAYVTNLSYY HLVPFETDIL D
