PXDC2_MOUSE
ID PXDC2_MOUSE Reviewed; 530 AA.
AC Q9DC11; Q6PET5; Q91ZV6;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Plexin domain-containing protein 2;
DE AltName: Full=Tumor endothelial marker 7-related protein;
DE Flags: Precursor;
GN Name=Plxdc2; Synonyms=Tem7r;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=11559528;
RA Carson-Walter E.B., Watkins D.N., Nanda A., Vogelstein B., Kinzler K.W.,
RA St Croix B.;
RT "Cell surface tumor endothelial markers are conserved in mice and humans.";
RL Cancer Res. 61:6649-6655(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NMRI; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP INTERACTION WITH CTTN.
RX PubMed=15574754; DOI=10.1158/0008-5472.can-04-2716;
RA Nanda A., Buckhaults P., Seaman S., Agrawal N., Boutin P., Shankara S.,
RA Nacht M., Teicher B., Stampfl J., Singh S., Vogelstein B., Kinzler K.W.,
RA St Croix B.;
RT "Identification of a binding partner for the endothelial cell surface
RT proteins TEM7 and TEM7R.";
RL Cancer Res. 64:8507-8511(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-507, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Lung, Pancreas, Spleen,
RC and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in tumor angiogenesis.
CC {ECO:0000269|PubMed:11559528}.
CC -!- SUBUNIT: Interacts with CTTN. {ECO:0000269|PubMed:15574754}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in tumor endothelium and in vessels of
CC some normal tissues, such as the muscle and lung.
CC {ECO:0000269|PubMed:11559528}.
CC -!- SIMILARITY: Belongs to the plexin family. {ECO:0000305}.
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DR EMBL; AF378761; AAL11998.1; -; mRNA.
DR EMBL; AK004640; BAB23431.1; -; mRNA.
DR EMBL; AK154921; BAE32927.1; -; mRNA.
DR EMBL; BC057881; AAH57881.1; -; mRNA.
DR CCDS; CCDS15705.1; -.
DR RefSeq; NP_080438.2; NM_026162.6.
DR AlphaFoldDB; Q9DC11; -.
DR BioGRID; 212194; 3.
DR STRING; 10090.ENSMUSP00000028081; -.
DR GlyGen; Q9DC11; 2 sites.
DR iPTMnet; Q9DC11; -.
DR PhosphoSitePlus; Q9DC11; -.
DR CPTAC; non-CPTAC-3935; -.
DR EPD; Q9DC11; -.
DR jPOST; Q9DC11; -.
DR MaxQB; Q9DC11; -.
DR PaxDb; Q9DC11; -.
DR PeptideAtlas; Q9DC11; -.
DR PRIDE; Q9DC11; -.
DR ProteomicsDB; 301928; -.
DR Antibodypedia; 25453; 172 antibodies from 31 providers.
DR DNASU; 67448; -.
DR Ensembl; ENSMUST00000028081; ENSMUSP00000028081; ENSMUSG00000026748.
DR GeneID; 67448; -.
DR KEGG; mmu:67448; -.
DR UCSC; uc008ikz.2; mouse.
DR CTD; 84898; -.
DR MGI; MGI:1914698; Plxdc2.
DR VEuPathDB; HostDB:ENSMUSG00000026748; -.
DR eggNOG; KOG3848; Eukaryota.
DR GeneTree; ENSGT00440000033408; -.
DR InParanoid; Q9DC11; -.
DR OMA; XIPVLVT; -.
DR OrthoDB; 1361987at2759; -.
DR PhylomeDB; Q9DC11; -.
DR TreeFam; TF314400; -.
DR BioGRID-ORCS; 67448; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Plxdc2; mouse.
DR PRO; PR:Q9DC11; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9DC11; protein.
DR Bgee; ENSMUSG00000026748; Expressed in vestibular membrane of cochlear duct and 254 other tissues.
DR ExpressionAtlas; Q9DC11; baseline and differential.
DR Genevisible; Q9DC11; MM.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR031152; PLXDC.
DR InterPro; IPR031154; PLXDC2.
DR InterPro; IPR016201; PSI.
DR PANTHER; PTHR13055; PTHR13055; 1.
DR PANTHER; PTHR13055:SF11; PTHR13055:SF11; 1.
DR Pfam; PF01437; PSI; 1.
DR SMART; SM00423; PSI; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..30
FT /evidence="ECO:0000255"
FT CHAIN 31..530
FT /note="Plexin domain-containing protein 2"
FT /id="PRO_0000234575"
FT TOPO_DOM 31..455
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 456..476
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 477..530
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 327..372
FT /note="PSI"
FT REGION 378..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 507
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 160
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 5
FT /note="R -> W (in Ref. 3; AAH57881)"
FT /evidence="ECO:0000305"
FT CONFLICT 26
FT /note="Q -> H (in Ref. 1; AAL11998)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 530 AA; 59616 MW; FB956C020735E36D CRC64;
MARFRRADLA AAGVMLLCHF LTDRFQFAHG EPGHHTNDWI YEVTNAFPWN EEGVEVDSQA
YNHRWKRNVD PFKAVDTNRA SMGQASPESK GFTDLLLDDG QDNNTQIEED TDHNYYISRI
YGPADSASRD LWVNIDQMEK DKVKIHGILS NTHRQAARVN LSFDFPFYGH FLNEVTVATG
GFIYTGEVVH RMLTATQYIA PLMANFDPSV SRNSTVRYFD NGTALVVQWD HVHLQDNYNL
GSFTFQATLL MDGRIIFGYK EIPVLVTQIS STNHPVKVGL SDAFVVVHRI QQIPNVRRRT
IYEYHRVELQ MSKITNISAV EMTPLPTCLQ FNGCGPCVSS QIGFNCSWCS KLQRCSSGFD
RHRQDWVDSG CPEEVQSKEK MCEKTEPGET SQTTTTSHTT TMQFRVLTTT RRAVTSQMPT
SLPTEDDTKI ALHLKDSGAS TDDSAAEKKG GTLHAGLIVG ILILVLIIAA AILVTVYMYH
HPTSAASIFF IERRPSRWPA MKFRRGSGHP AYAEVEPVGE KEGFIVSEQC
