ID   PXL2A_DANRE             Reviewed;         212 AA.
AC   Q6PBP3;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 2.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Peroxiredoxin-like 2A;
DE   AltName: Full=Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes;
DE            Short=Protein PAMM;
DE   AltName: Full=Redox-regulatory protein FAM213A;
GN   Name=prxl2a; Synonyms=fam213a, pamm; ORFNames=zgc:73311;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Kidney marrow;
RX   PubMed=15520368; DOI=10.1073/pnas.0407241101;
RA   Song H.-D., Sun X.-J., Deng M., Zhang G.-W., Zhou Y., Wu X.-Y., Sheng Y.,
RA   Chen Y., Ruan Z., Jiang C.-L., Fan H.-Y., Zon L.I., Kanki J.P., Liu T.X.,
RA   Look A.T., Chen Z.;
RT   "Hematopoietic gene expression profile in zebrafish kidney marrow.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:16240-16245(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SELENOCYSTEINE AT SEC-74, AND DEVELOPMENTAL STAGE.
RX   PubMed=14710190; DOI=10.1038/sj.embor.7400036;
RA   Castellano S., Novoselov S.V., Kryukov G.V., Lescure A., Blanco E.,
RA   Krol A., Gladyshev V.N., Guigo R.;
RT   "Reconsidering the evolution of eukaryotic selenoproteins: a novel
RT   nonmammalian family with scattered phylogenetic distribution.";
RL   EMBO Rep. 5:71-77(2004).
CC   -!- FUNCTION: Involved in redox regulation of the cell. Acts as an
CC       antioxidant (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in kidney marrow.
CC       {ECO:0000269|PubMed:15520368}.
CC   -!- DEVELOPMENTAL STAGE: Widely expressed in all embryonic tissues from all
CC       stages. Expression is already detectable at the early stages from
CC       gastrula and somitogenesis, but within the embryonic tissues only;
CC       there is no expression within the nutrient cells of the yolk syncytial
CC       layer. Later in development, expression remains high and nonrestricted.
CC       {ECO:0000269|PubMed:14710190}.
CC   -!- MISCELLANEOUS: The active site Cys-77 corresponds to one of the redox-
CC       active cysteines of peroxiredoxins.
CC   -!- SIMILARITY: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH59634.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
CC       Sequence=AAQ91253.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AY391441; AAQ91253.1; ALT_SEQ; mRNA.
DR   EMBL; BC059634; AAH59634.1; ALT_SEQ; mRNA.
DR   RefSeq; NP_001180454.1; NM_001193525.1.
DR   STRING; 7955.ENSDARP00000074475; -.
DR   PaxDb; Q6PBP3; -.
DR   Ensembl; ENSDART00000147905; ENSDARP00000115912; ENSDARG00000057378.
DR   Ensembl; ENSDART00000188249; ENSDARP00000149078; ENSDARG00000057378.
DR   GeneID; 323739; -.
DR   KEGG; dre:323739; -.
DR   CTD; 323739; -.
DR   ZFIN; ZDB-GENE-030131-2459; selenou1a.
DR   eggNOG; KOG4498; Eukaryota.
DR   GeneTree; ENSGT00940000164872; -.
DR   HOGENOM; CLU_086062_0_0_1; -.
DR   InParanoid; Q6PBP3; -.
DR   OMA; KFYGPQK; -.
DR   OrthoDB; 1442607at2759; -.
DR   PhylomeDB; Q6PBP3; -.
DR   PRO; PR:Q6PBP3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 13.
DR   Bgee; ENSDARG00000057378; Expressed in liver and 26 other tissues.
DR   ExpressionAtlas; Q6PBP3; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016209; F:antioxidant activity; IBA:GO_Central.
DR   InterPro; IPR032802; PRXL2A.
DR   InterPro; IPR032801; PXL2A/B/C.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR28630; PTHR28630; 1.
DR   PANTHER; PTHR28630:SF3; PTHR28630:SF3; 1.
DR   Pfam; PF13911; AhpC-TSA_2; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Antioxidant; Cytoplasm; Redox-active center; Reference proteome;
KW   Selenocysteine.
FT   CHAIN           1..212
FT                   /note="Peroxiredoxin-like 2A"
FT                   /id="PRO_0000398783"
FT   REGION          3..101
FT                   /note="Thioredoxin fold"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        77
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000250"
FT   NON_STD         74
FT                   /note="Selenocysteine"
FT                   /evidence="ECO:0000269|PubMed:14710190"
SQ   SEQUENCE   212 AA;  23043 MW;  6B2C20B7244925AB CRC64;
     MGMWSLGLGA VGAAIAGLIL ANTDFLLTKS APATVDYLAN ADLKTIDGDE RSLKAKALWE
     KSGAVIMAVR RPGUFLCREE ASELSSLKPQ LDELGVPLYA VVKENVGTEI QDFRPHFAGE
     IFLDEKQAFY GPQQRKMGGL GFIRLGVWQN FVRAWRAGYQ GNMNGEGFIL GGVFVMGSGG
     QGVLLEHREK EFGDKVSLES VLEAAKKVVV EK