PXL2A_XENLA
ID PXL2A_XENLA Reviewed; 227 AA.
AC Q641F0;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Peroxiredoxin-like 2A;
DE AltName: Full=Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes;
DE Short=Protein PAMM;
DE AltName: Full=Redox-regulatory protein FAM213A;
GN Name=prxl2a; Synonyms=fam213a, pamm;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in redox regulation of the cell. Acts as an
CC antioxidant (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- MISCELLANEOUS: The active site cysteines correspond to the redox-active
CC cysteines of peroxiredoxins.
CC -!- SIMILARITY: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A
CC subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH82387.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH82387.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; BC082387; AAH82387.1; ALT_SEQ; mRNA.
DR RefSeq; NP_001087861.1; NM_001094392.1.
DR AlphaFoldDB; Q641F0; -.
DR SMR; Q641F0; -.
DR GeneID; 447722; -.
DR KEGG; xla:447722; -.
DR CTD; 447722; -.
DR Xenbase; XB-GENE-962672; prxl2a.L.
DR Proteomes; UP000186698; Chromosome 7L.
DR Bgee; 447722; Expressed in camera-type eye and 19 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016209; F:antioxidant activity; IEA:UniProtKB-KW.
DR InterPro; IPR032802; PRXL2A.
DR InterPro; IPR032801; PXL2A/B/C.
DR PANTHER; PTHR28630; PTHR28630; 1.
DR PANTHER; PTHR28630:SF3; PTHR28630:SF3; 1.
DR Pfam; PF13911; AhpC-TSA_2; 1.
PE 2: Evidence at transcript level;
KW Antioxidant; Cytoplasm; Redox-active center; Reference proteome.
FT CHAIN 1..227
FT /note="Peroxiredoxin-like 2A"
FT /id="PRO_0000398784"
FT REGION 13..111
FT /note="Thioredoxin fold"
FT /evidence="ECO:0000250"
FT ACT_SITE 84
FT /note="Redox-active"
FT /evidence="ECO:0000250"
FT ACT_SITE 87
FT /note="Redox-active"
FT /evidence="ECO:0000250"
SQ SEQUENCE 227 AA; 25221 MW; C241D04ED2E92F60 CRC64;
MFDLSDQLIT MGLWSISIGA FGAAVAGILL ANTDFFLSQT EKATLDYLEE TELKTIGEEP
RLFKAKDLWE RDGAVIMAVR RPGCFLCREE ASGLSTLKPQ LDQLGVPLYA IVKENIGNEV
EHFQPYFNGK VFLDAKGQFY GPQKRKMMLL GLVRLGVWQN FRRAWKGGFE GNLEGEGLIL
GGMFVIGSGK QGILLEHREK EFGDKANLTA VLDAARKISK QTAQNDN