PXL2A_XENTR
ID PXL2A_XENTR Reviewed; 227 AA.
AC A0JPD7;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 1.
DT 03-AUG-2022, entry version 76.
DE RecName: Full=Peroxiredoxin-like 2A;
DE AltName: Full=Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes;
DE Short=Protein PAMM;
DE AltName: Full=Redox-regulatory protein FAM213A;
GN Name=prxl2a; Synonyms=fam213a, pamm;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in redox regulation of the cell. Acts as an
CC antioxidant (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A
CC subfamily. {ECO:0000305}.
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DR EMBL; BC127374; AAI27375.1; -; mRNA.
DR RefSeq; NP_001090691.1; NM_001097222.2.
DR AlphaFoldDB; A0JPD7; -.
DR SMR; A0JPD7; -.
DR STRING; 8364.ENSXETP00000020353; -.
DR PaxDb; A0JPD7; -.
DR GeneID; 100036669; -.
DR KEGG; xtr:100036669; -.
DR CTD; 84293; -.
DR Xenbase; XB-GENE-962667; prxl2a.
DR eggNOG; KOG4498; Eukaryota.
DR HOGENOM; CLU_086062_0_0_1; -.
DR InParanoid; A0JPD7; -.
DR OMA; KFYGPQK; -.
DR OrthoDB; 1442607at2759; -.
DR PhylomeDB; A0JPD7; -.
DR TreeFam; TF313804; -.
DR Proteomes; UP000008143; Chromosome 7.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000003529; Expressed in testis and 13 other tissues.
DR ExpressionAtlas; A0JPD7; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016209; F:antioxidant activity; IBA:GO_Central.
DR InterPro; IPR032802; PRXL2A.
DR InterPro; IPR032801; PXL2A/B/C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR28630; PTHR28630; 1.
DR PANTHER; PTHR28630:SF3; PTHR28630:SF3; 1.
DR Pfam; PF13911; AhpC-TSA_2; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 2: Evidence at transcript level;
KW Antioxidant; Cytoplasm; Redox-active center; Reference proteome.
FT CHAIN 1..227
FT /note="Peroxiredoxin-like 2A"
FT /id="PRO_0000398785"
FT REGION 13..111
FT /note="Thioredoxin fold"
FT /evidence="ECO:0000250"
FT ACT_SITE 84
FT /note="Redox-active"
FT /evidence="ECO:0000250"
FT ACT_SITE 87
FT /note="Redox-active"
FT /evidence="ECO:0000250"
SQ SEQUENCE 227 AA; 25230 MW; 309A6C095567F3DB CRC64;
MFDLSDQLIA MGLWSISIGA FGAAVAGILL ANTDLFLTQT EEATLDYLEE TELKAIGDEP
KSFKAKDLWE KNGAVVMAVR RPGCFLCREE ASDLSSLKSQ LDQLGVPLYA VVKENIGNEV
EQFQPYFNGK IFLDEKGKFY GPQKRKMMFL GLVRLGVWQN FRRAWKGGFE GNLEGEGLIL
GGMFVIGSGK QGILLEHREK EFGDKANLTA VLDAARKINK QRAQNDN