PXL2B_XENLA
ID PXL2B_XENLA Reviewed; 201 AA.
AC Q6AZG8;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Prostamide/prostaglandin F synthase;
DE Short=Prostamide/PG F synthase;
DE Short=Prostamide/PGF synthase;
DE EC=1.11.1.20 {ECO:0000250|UniProtKB:Q9DB60};
DE AltName: Full=Peroxiredoxin-like 2B;
GN Name=prxl2b; Synonyms=fam213b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the reduction of prostaglandin-ethanolamide H(2)
CC (prostamide H(2)) to prostamide F(2alpha) with NADPH as proton donor.
CC Also able to reduce prostaglandin H(2) to prostaglandin F(2alpha) (By
CC similarity). {ECO:0000250|UniProtKB:Q9DB60}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[thioredoxin]-dithiol + prostaglandin H2 = [thioredoxin]-
CC disulfide + prostaglandin F2alpha; Xref=Rhea:RHEA:28214, Rhea:RHEA-
CC COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:29950,
CC ChEBI:CHEBI:50058, ChEBI:CHEBI:57404, ChEBI:CHEBI:57405;
CC EC=1.11.1.20; Evidence={ECO:0000250|UniProtKB:Q9DB60};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[thioredoxin]-disulfide + prostamide F2alpha = [thioredoxin]-
CC dithiol + prostamide H2; Xref=Rhea:RHEA:26373, Rhea:RHEA-COMP:10698,
CC Rhea:RHEA-COMP:10700, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC ChEBI:CHEBI:53081, ChEBI:CHEBI:53082; EC=1.11.1.20;
CC Evidence={ECO:0000250|UniProtKB:Q9DB60};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:Q9DB60}.
CC -!- SIMILARITY: Belongs to the peroxiredoxin-like PRXL2 family.
CC Prostamide/prostaglandin F synthase subfamily. {ECO:0000305}.
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DR EMBL; BC078028; AAH78028.1; -; mRNA.
DR RefSeq; NP_001087128.1; NM_001093659.1.
DR AlphaFoldDB; Q6AZG8; -.
DR BioGRID; 103877; 1.
DR MaxQB; Q6AZG8; -.
DR DNASU; 447017; -.
DR GeneID; 447017; -.
DR KEGG; xla:447017; -.
DR CTD; 447017; -.
DR Xenbase; XB-GENE-6254580; prxl2b.L.
DR OMA; QRPVCND; -.
DR OrthoDB; 1255928at2759; -.
DR Proteomes; UP000186698; Chromosome 7L.
DR Bgee; 447017; Expressed in liver and 20 other tissues.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; ISS:UniProtKB.
DR GO; GO:0001516; P:prostaglandin biosynthetic process; ISS:UniProtKB.
DR InterPro; IPR032801; PXL2A/B/C.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR28630; PTHR28630; 1.
DR Pfam; PF13911; AhpC-TSA_2; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Fatty acid biosynthesis; Fatty acid metabolism;
KW Lipid biosynthesis; Lipid metabolism; NADP; Oxidoreductase;
KW Prostaglandin biosynthesis; Prostaglandin metabolism; Reference proteome.
FT CHAIN 1..201
FT /note="Prostamide/prostaglandin F synthase"
FT /id="PRO_0000284641"
SQ SEQUENCE 201 AA; 22013 MW; DE6A02E0CEB5DA47 CRC64;
MGSLDLAKAG AILVKNALSG EMVELKSLWK EQTTVLLFLR RFGCQICRWI AKDMGKLKES
CDVHQIRLVG IGPEEVGLKE FLDGNFFNGE LYIDDSKQSY KDLGFKRYSA LSVIPAALGK
KVRDIVTKAN ADGVQGNFSG DLLQSGGMLI VSKGGEKVLL HFIQDSPGDY VPLETIVQTL
GITANVTESQ RPQCNDDVCT R