ID   PXL2C_BOVIN             Reviewed;         228 AA.
AC   Q148E0;
DT   19-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Peroxiredoxin-like 2C;
DE   AltName: Full=AhpC/TSA antioxidant enzyme domain-containing protein 1;
DE   AltName: Full=Thioredoxin-like protein AAED1;
GN   Name=PRXL2C; Synonyms=AAED1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal cerebellum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May regulate positively ERK1/2 signaling and AKT1 activation
CC       leading to HIF1A up-regulation with an increased expression of
CC       glycolysis genes and enhanced glycolysis.
CC       {ECO:0000250|UniProtKB:Q7RTV5}.
CC   -!- SIMILARITY: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2C
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC118425; AAI18426.1; -; mRNA.
DR   RefSeq; NP_001069904.1; NM_001076436.2.
DR   AlphaFoldDB; Q148E0; -.
DR   STRING; 9913.ENSBTAP00000027653; -.
DR   PaxDb; Q148E0; -.
DR   PRIDE; Q148E0; -.
DR   Ensembl; ENSBTAT00000027653; ENSBTAP00000027653; ENSBTAG00000020749.
DR   GeneID; 616897; -.
DR   KEGG; bta:616897; -.
DR   CTD; 195827; -.
DR   VEuPathDB; HostDB:ENSBTAG00000020749; -.
DR   VGNC; VGNC:25441; PRXL2C.
DR   eggNOG; KOG4498; Eukaryota.
DR   GeneTree; ENSGT00510000048363; -.
DR   HOGENOM; CLU_035338_2_0_1; -.
DR   InParanoid; Q148E0; -.
DR   OMA; DMDDVLK; -.
DR   OrthoDB; 1255928at2759; -.
DR   TreeFam; TF329293; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000020749; Expressed in caput epididymis and 105 other tissues.
DR   GO; GO:0016209; F:antioxidant activity; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
DR   GO; GO:0045821; P:positive regulation of glycolytic process; ISS:UniProtKB.
DR   InterPro; IPR032801; PXL2A/B/C.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR28630; PTHR28630; 1.
DR   Pfam; PF13911; AhpC-TSA_2; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..228
FT                   /note="Peroxiredoxin-like 2C"
FT                   /id="PRO_0000249460"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   228 AA;  25137 MW;  45495130FD1E4032 CRC64;
     MAAPSEAPVT RQVSGHAAPA PVPSGPASWQ PLAAAVAELP VLDASGRPVL FGELFRERRA
     IVVFVRHFLC YICKEYVEDL AKIPKSFLQE ANVTLIVIGQ SSYHHIEPFC KLTGYSHEIY
     VDPEREIYKR LGMKRGEEIA SSGQSPHVKS NILSGSIRSL WRAVTGPLFD FQGDPAQQGG
     TLILGPGNNI HFIHHDRNRL DHKPINSVLQ LVGVQHVDFT SRPSVIHV