ID   PXL2C_HUMAN             Reviewed;         226 AA.
AC   Q7RTV5; B2RMW4; Q5JU02;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Peroxiredoxin-like 2C {ECO:0000305};
DE   AltName: Full=AhpC/TSA antioxidant enzyme domain-containing protein 1;
DE   AltName: Full=Thioredoxin-like protein AAED1;
GN   Name=PRXL2C {ECO:0000312|HGNC:HGNC:16881};
GN   Synonyms=AAED1 {ECO:0000312|HGNC:HGNC:16881}, C9orf21;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA   Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA   Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA   Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA   Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA   Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA   Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA   Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA   Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA   Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA   Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA   Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA   McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA   Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA   Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA   Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA   Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA   West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA   Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA   Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=12234665; DOI=10.1016/s0378-1119(02)00793-x;
RA   Gilligan P., Brenner S., Venkatesh B.;
RT   "Fugu and human sequence comparison identifies novel human genes and
RT   conserved non-coding sequences.";
RL   Gene 294:35-44(2002).
RN   [5]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=29901208; DOI=10.3892/or.2018.6478;
RA   Zhang B., Wu J., Cai Y., Luo M., Wang B., Gu Y.;
RT   "AAED1 modulates proliferation and glycolysis in gastric cancer.";
RL   Oncol. Rep. 40:1156-1164(2018).
CC   -!- FUNCTION: May regulate positively ERK1/2 signaling and AKT1 activation
CC       leading to HIF1A up-regulation with an increased expression of
CC       glycolysis genes and enhanced glycolysis.
CC       {ECO:0000269|PubMed:29901208}.
CC   -!- TISSUE SPECIFICITY: Expressed in gastric tissues.
CC       {ECO:0000269|PubMed:29901208}.
CC   -!- SIMILARITY: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2C
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AL353578; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471174; EAW92662.1; -; Genomic_DNA.
DR   EMBL; BC136503; AAI36504.1; -; mRNA.
DR   EMBL; BK000255; DAA00065.1; -; mRNA.
DR   CCDS; CCDS35073.1; -.
DR   RefSeq; NP_714542.1; NM_153698.1.
DR   AlphaFoldDB; Q7RTV5; -.
DR   BioGRID; 128185; 2.
DR   IntAct; Q7RTV5; 1.
DR   STRING; 9606.ENSP00000364382; -.
DR   iPTMnet; Q7RTV5; -.
DR   PhosphoSitePlus; Q7RTV5; -.
DR   BioMuta; AAED1; -.
DR   EPD; Q7RTV5; -.
DR   jPOST; Q7RTV5; -.
DR   MassIVE; Q7RTV5; -.
DR   MaxQB; Q7RTV5; -.
DR   PaxDb; Q7RTV5; -.
DR   PeptideAtlas; Q7RTV5; -.
DR   PRIDE; Q7RTV5; -.
DR   Antibodypedia; 14235; 40 antibodies from 9 providers.
DR   DNASU; 195827; -.
DR   Ensembl; ENST00000375234.8; ENSP00000364382.3; ENSG00000158122.12.
DR   GeneID; 195827; -.
DR   KEGG; hsa:195827; -.
DR   MANE-Select; ENST00000375234.8; ENSP00000364382.3; NM_153698.2; NP_714542.1.
DR   UCSC; uc004awm.4; human.
DR   CTD; 195827; -.
DR   DisGeNET; 195827; -.
DR   GeneCards; PRXL2C; -.
DR   HGNC; HGNC:16881; PRXL2C.
DR   HPA; ENSG00000158122; Low tissue specificity.
DR   neXtProt; NX_Q7RTV5; -.
DR   OpenTargets; ENSG00000158122; -.
DR   PharmGKB; PA38190; -.
DR   VEuPathDB; HostDB:ENSG00000158122; -.
DR   eggNOG; KOG4498; Eukaryota.
DR   GeneTree; ENSGT00510000048363; -.
DR   InParanoid; Q7RTV5; -.
DR   OMA; DMDDVLK; -.
DR   OrthoDB; 1255928at2759; -.
DR   PhylomeDB; Q7RTV5; -.
DR   TreeFam; TF329293; -.
DR   PathwayCommons; Q7RTV5; -.
DR   SignaLink; Q7RTV5; -.
DR   BioGRID-ORCS; 195827; 9 hits in 1073 CRISPR screens.
DR   ChiTaRS; AAED1; human.
DR   GenomeRNAi; 195827; -.
DR   Pharos; Q7RTV5; Tdark.
DR   PRO; PR:Q7RTV5; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   RNAct; Q7RTV5; protein.
DR   Bgee; ENSG00000158122; Expressed in left ventricle myocardium and 163 other tissues.
DR   ExpressionAtlas; Q7RTV5; baseline and differential.
DR   Genevisible; Q7RTV5; HS.
DR   GO; GO:0016209; F:antioxidant activity; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.
DR   GO; GO:0045821; P:positive regulation of glycolytic process; IMP:UniProtKB.
DR   InterPro; IPR032801; PXL2A/B/C.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR28630; PTHR28630; 1.
DR   Pfam; PF13911; AhpC-TSA_2; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..226
FT                   /note="Peroxiredoxin-like 2C"
FT                   /id="PRO_0000221624"
FT   VARIANT         83
FT                   /note="R -> K (in dbSNP:rs9886834)"
FT                   /id="VAR_052598"
SQ   SEQUENCE   226 AA;  24857 MW;  2C6D01B15C8F8738 CRC64;
     MAAPAPVTRQ VSGAAALVPA PSGPDSGQPL AAAVAELPVL DARGQRVPFG ALFRERRAVV
     VFVRHFLCYI CKEYVEDLAK IPRSFLQEAN VTLIVIGQSS YHHIEPFCKL TGYSHEIYVD
     PEREIYKRLG MKRGEEIASS GQSPHIKSNL LSGSLQSLWR AVTGPLFDFQ GDPAQQGGTL
     ILGPGNNIHF IHRDRNRLDH KPINSVLQLV GVQHVNFTNR PSVIHV