ID   PXL2C_MOUSE             Reviewed;         226 AA.
AC   Q9D1A0; Q3UFP2; Q9CVT8;
DT   13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Peroxiredoxin-like 2C {ECO:0000305};
DE   AltName: Full=AhpC/TSA antioxidant enzyme domain-containing protein 1;
DE   AltName: Full=Thioredoxin-like protein AAED1;
GN   Name=Prxl2c; Synonyms=Aaed1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
CC   -!- FUNCTION: May regulate positively ERK1/2 signaling and AKT1 activation
CC       leading to HIF1A up-regulation with an increased expression of
CC       glycolysis genes and enhanced glycolysis.
CC       {ECO:0000250|UniProtKB:Q7RTV5}.
CC   -!- SIMILARITY: Belongs to the peroxiredoxin-like PRXL2 family. PRXL2C
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AK003782; BAB22993.1; -; mRNA.
DR   EMBL; AK006589; BAB24662.1; -; mRNA.
DR   EMBL; AK148379; BAE28518.1; -; mRNA.
DR   CCDS; CCDS26599.1; -.
DR   RefSeq; NP_079646.1; NM_025370.2.
DR   AlphaFoldDB; Q9D1A0; -.
DR   BioGRID; 211237; 1.
DR   STRING; 10090.ENSMUSP00000021938; -.
DR   iPTMnet; Q9D1A0; -.
DR   PhosphoSitePlus; Q9D1A0; -.
DR   EPD; Q9D1A0; -.
DR   MaxQB; Q9D1A0; -.
DR   PaxDb; Q9D1A0; -.
DR   PRIDE; Q9D1A0; -.
DR   ProteomicsDB; 286009; -.
DR   Antibodypedia; 14235; 40 antibodies from 9 providers.
DR   DNASU; 66129; -.
DR   Ensembl; ENSMUST00000222570; ENSMUSP00000152323; ENSMUSG00000021482.
DR   GeneID; 66129; -.
DR   KEGG; mmu:66129; -.
DR   UCSC; uc007qyt.1; mouse.
DR   CTD; 195827; -.
DR   MGI; MGI:1913379; Prxl2c.
DR   VEuPathDB; HostDB:ENSMUSG00000021482; -.
DR   eggNOG; KOG4498; Eukaryota.
DR   GeneTree; ENSGT00510000048363; -.
DR   HOGENOM; CLU_035338_2_0_1; -.
DR   InParanoid; Q9D1A0; -.
DR   OMA; DMDDVLK; -.
DR   OrthoDB; 1255928at2759; -.
DR   PhylomeDB; Q9D1A0; -.
DR   TreeFam; TF329293; -.
DR   BioGRID-ORCS; 66129; 2 hits in 72 CRISPR screens.
DR   ChiTaRS; Prxl2c; mouse.
DR   PRO; PR:Q9D1A0; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   RNAct; Q9D1A0; protein.
DR   Bgee; ENSMUSG00000021482; Expressed in iris and 213 other tissues.
DR   ExpressionAtlas; Q9D1A0; baseline and differential.
DR   Genevisible; Q9D1A0; MM.
DR   GO; GO:0016209; F:antioxidant activity; IBA:GO_Central.
DR   GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
DR   GO; GO:0045821; P:positive regulation of glycolytic process; ISS:UniProtKB.
DR   InterPro; IPR032801; PXL2A/B/C.
DR   InterPro; IPR036249; Thioredoxin-like_sf.
DR   PANTHER; PTHR28630; PTHR28630; 1.
DR   Pfam; PF13911; AhpC-TSA_2; 1.
DR   SUPFAM; SSF52833; SSF52833; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..226
FT                   /note="Peroxiredoxin-like 2C"
FT                   /id="PRO_0000221625"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   226 AA;  24904 MW;  9E256CFDEB76FB99 CRC64;
     MAAPVTRQVS GCAGRVPSPA GSVTERGQPL AAAVAELPVL DASGRRVTFG ALFRERRAVV
     VFVRHFLCYV CKEYVEDLAK IPKSVLREAD VTLIVIGQSS YHHIEPFCKL TGYSHEIYVD
     PEREIYKRLG MKRGEEISSS GQSPHIKSNL LSGSLQSLWR AVTGPLFDFQ GDPAQQGGTL
     ILGPGNNIHF VHRDRNRLDH KPINSVLQLV GVQPVNFMSR PTVIHV