ID   PXMP2_BOVIN             Reviewed;         196 AA.
AC   Q2KIY1;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Peroxisomal membrane protein 2;
GN   Name=PXMP2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Testis;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Seems to be involved in pore-forming activity and may
CC       contribute to the unspecific permeability of the peroxisomal membrane.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with PEX19 and SIVA1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC       {ECO:0000305}.
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DR   EMBL; BC112465; AAI12466.1; -; mRNA.
DR   RefSeq; NP_001039473.1; NM_001046008.2.
DR   AlphaFoldDB; Q2KIY1; -.
DR   STRING; 9913.ENSBTAP00000009885; -.
DR   PaxDb; Q2KIY1; -.
DR   GeneID; 508609; -.
DR   KEGG; bta:508609; -.
DR   CTD; 5827; -.
DR   eggNOG; KOG1944; Eukaryota.
DR   HOGENOM; CLU_049109_7_1_1; -.
DR   InParanoid; Q2KIY1; -.
DR   OrthoDB; 1324608at2759; -.
DR   TreeFam; TF105311; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005778; C:peroxisomal membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007248; Mpv17_PMP22.
DR   PANTHER; PTHR11266; PTHR11266; 1.
DR   Pfam; PF04117; Mpv17_PMP22; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Peroxisome; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..196
FT                   /note="Peroxisomal membrane protein 2"
FT                   /id="PRO_0000245253"
FT   TOPO_DOM        1..30
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        52..76
FT                   /note="Peroxisomal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        98..115
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        137..174
FT                   /note="Peroxisomal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        175..196
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   196 AA;  22259 MW;  661BEF198EA414E3 CRC64;
     MAPAASKLRA EAGLGPLPRR ALSQYLRLLR LYPVLTKAAT SGILSALGNF LAQLIEKKQK
     KENCSQKLDV SGPLRYAIYG FFFTGPLGHF FYLLMERWIP SEVPLAGIKR LLLDRLLFAP
     AFLSLFFLVM NFLEGQDTAA FAAKMKSGFW PALRMNWRVW TPVQFININY IPVQFRVLFA
     NLVALFWYAY LASLGK