ID   PXMP2_HUMAN             Reviewed;         195 AA.
AC   Q9NR77;
DT   27-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 153.
DE   RecName: Full=Peroxisomal membrane protein 2;
DE   AltName: Full=22 kDa peroxisomal membrane protein;
GN   Name=PXMP2; Synonyms=PMP22;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Bani M.R., Giavazzi R.;
RT   "Modulation of endothelium by tumor environment.";
RL   Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Retina;
RX   PubMed=11590176; DOI=10.1074/jbc.m108155200;
RA   Brosius U., Dehmel T., Gaertner J.;
RT   "Two different targeting signals direct human peroxisomal membrane protein
RT   22 to peroxisomes.";
RL   J. Biol. Chem. 277:774-784(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Retinoblastoma;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   INTERACTION WITH PEX19.
RX   PubMed=10704444; DOI=10.1083/jcb.148.5.931;
RA   Sacksteder K.A., Jones J.M., South S.T., Li X., Liu Y., Gould S.J.;
RT   "PEX19 binds multiple peroxisomal membrane proteins, is predominantly
RT   cytoplasmic, and is required for peroxisome membrane synthesis.";
RL   J. Cell Biol. 148:931-944(2000).
RN   [5]
RP   INTERACTION WITH SIVA1.
RX   PubMed=16683188; DOI=10.1007/s11010-005-9082-6;
RA   Nestler M., Martin U., Hortschansky P., Saluz H.-P., Henke A., Munder T.;
RT   "The zinc containing pro-apoptotic protein siva interacts with the
RT   peroxisomal membrane protein pmp22.";
RL   Mol. Cell. Biochem. 287:147-155(2006).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
CC   -!- FUNCTION: Seems to be involved in pore-forming activity and may
CC       contribute to the unspecific permeability of the peroxisomal membrane.
CC   -!- SUBUNIT: Interacts with PEX19 and SIVA1. {ECO:0000269|PubMed:10704444,
CC       ECO:0000269|PubMed:16683188}.
CC   -!- INTERACTION:
CC       Q9NR77; P40855: PEX19; NbExp=3; IntAct=EBI-1392944, EBI-594747;
CC       Q9NR77; O15304: SIVA1; NbExp=3; IntAct=EBI-1392944, EBI-520756;
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC       {ECO:0000305}.
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DR   EMBL; AF250136; AAF73963.1; -; mRNA.
DR   EMBL; AY044439; AAK95858.1; -; mRNA.
DR   EMBL; BC073997; AAH73997.1; -; mRNA.
DR   CCDS; CCDS9279.1; -.
DR   RefSeq; NP_061133.1; NM_018663.2.
DR   AlphaFoldDB; Q9NR77; -.
DR   BioGRID; 111785; 280.
DR   IntAct; Q9NR77; 15.
DR   MINT; Q9NR77; -.
DR   STRING; 9606.ENSP00000321271; -.
DR   TCDB; 1.A.126.1.3; the mpv17/pmp22 4 tms putative channel (mpv17) family.
DR   iPTMnet; Q9NR77; -.
DR   PhosphoSitePlus; Q9NR77; -.
DR   BioMuta; PXMP2; -.
DR   DMDM; 27923831; -.
DR   EPD; Q9NR77; -.
DR   jPOST; Q9NR77; -.
DR   MassIVE; Q9NR77; -.
DR   MaxQB; Q9NR77; -.
DR   PaxDb; Q9NR77; -.
DR   PeptideAtlas; Q9NR77; -.
DR   PRIDE; Q9NR77; -.
DR   ProteomicsDB; 82292; -.
DR   TopDownProteomics; Q9NR77; -.
DR   Antibodypedia; 53709; 119 antibodies from 21 providers.
DR   DNASU; 5827; -.
DR   Ensembl; ENST00000317479.8; ENSP00000321271.3; ENSG00000176894.10.
DR   GeneID; 5827; -.
DR   KEGG; hsa:5827; -.
DR   MANE-Select; ENST00000317479.8; ENSP00000321271.3; NM_018663.3; NP_061133.1.
DR   UCSC; uc001ukt.3; human.
DR   CTD; 5827; -.
DR   DisGeNET; 5827; -.
DR   GeneCards; PXMP2; -.
DR   HGNC; HGNC:9716; PXMP2.
DR   HPA; ENSG00000176894; Tissue enhanced (liver).
DR   MIM; 617399; gene.
DR   neXtProt; NX_Q9NR77; -.
DR   OpenTargets; ENSG00000176894; -.
DR   PharmGKB; PA34059; -.
DR   VEuPathDB; HostDB:ENSG00000176894; -.
DR   eggNOG; KOG1944; Eukaryota.
DR   GeneTree; ENSGT00940000161539; -.
DR   HOGENOM; CLU_049109_7_1_1; -.
DR   InParanoid; Q9NR77; -.
DR   OMA; KGWEDFE; -.
DR   OrthoDB; 1324608at2759; -.
DR   PhylomeDB; Q9NR77; -.
DR   TreeFam; TF105311; -.
DR   PathwayCommons; Q9NR77; -.
DR   Reactome; R-HSA-389661; Glyoxylate metabolism and glycine degradation.
DR   Reactome; R-HSA-9603798; Class I peroxisomal membrane protein import.
DR   SignaLink; Q9NR77; -.
DR   BioGRID-ORCS; 5827; 10 hits in 1072 CRISPR screens.
DR   ChiTaRS; PXMP2; human.
DR   GenomeRNAi; 5827; -.
DR   Pharos; Q9NR77; Tbio.
DR   PRO; PR:Q9NR77; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q9NR77; protein.
DR   Bgee; ENSG00000176894; Expressed in right lobe of liver and 97 other tissues.
DR   ExpressionAtlas; Q9NR77; baseline and differential.
DR   Genevisible; Q9NR77; HS.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; HDA:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005778; C:peroxisomal membrane; IDA:UniProtKB.
DR   GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR   InterPro; IPR007248; Mpv17_PMP22.
DR   PANTHER; PTHR11266; PTHR11266; 1.
DR   Pfam; PF04117; Mpv17_PMP22; 1.
PE   1: Evidence at protein level;
KW   Membrane; Peroxisome; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..195
FT                   /note="Peroxisomal membrane protein 2"
FT                   /id="PRO_0000218929"
FT   TOPO_DOM        1..30
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        52..75
FT                   /note="Peroxisomal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        76..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        97..114
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        115..135
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..173
FT                   /note="Peroxisomal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   195 AA;  22253 MW;  9CA7FD67F8391E94 CRC64;
     MAPAASRLRA EAGLGALPRR ALAQYLLFLR LYPVLTKAAT SGILSALGNF LAQMIEKKRK
     KENSRSLDVG GPLRYAVYGF FFTGPLSHFF YFFMEHWIPP EVPLAGLRRL LLDRLVFAPA
     FLMLFFLIMN FLEGKDASAF AAKMRGGFWP ALRMNWRVWT PLQFININYV PLKFRVLFAN
     LAALFWYAYL ASLGK