PXMP2_MOUSE
ID PXMP2_MOUSE Reviewed; 194 AA.
AC P42925; Q9ERF1;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 138.
DE RecName: Full=Peroxisomal membrane protein 2;
DE AltName: Full=22 kDa peroxisomal membrane protein;
GN Name=Pxmp2; Synonyms=Pmp22;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Swiss Webster; TISSUE=Liver;
RX PubMed=7551822; DOI=10.1006/bmme.1995.1027;
RA Bryant D.D., Wilson G.N.;
RT "Differential evolution and expression of murine peroxisomal membrane
RT protein genes.";
RL Biochem. Mol. Med. 55:22-30(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=129/Sv;
RX PubMed=11470509; DOI=10.1016/s0378-1119(01)00531-5;
RA Luers G.H., Otte D.M., Subramani S., Franz T.;
RT "Genomic organization, chromosomal localization and tissue specific
RT expression of the murine Pxmp2 gene encoding the 22 kDa peroxisomal
RT membrane protein (Pmp22).";
RL Gene 272:45-50(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, and Liver;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Seems to be involved in pore-forming activity and may
CC contribute to the unspecific permeability of the peroxisomal membrane.
CC -!- SUBUNIT: Interacts with PEX19 and SIVA1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC {ECO:0000305}.
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DR EMBL; L28835; AAA39957.1; -; Genomic_DNA.
DR EMBL; AF309644; AAG25724.1; -; mRNA.
DR EMBL; AK003118; BAB22578.1; -; mRNA.
DR RefSeq; NP_033019.2; NM_008993.2.
DR AlphaFoldDB; P42925; -.
DR STRING; 10090.ENSMUSP00000031472; -.
DR iPTMnet; P42925; -.
DR PhosphoSitePlus; P42925; -.
DR jPOST; P42925; -.
DR MaxQB; P42925; -.
DR PaxDb; P42925; -.
DR PeptideAtlas; P42925; -.
DR PRIDE; P42925; -.
DR ProteomicsDB; 301932; -.
DR DNASU; 19301; -.
DR GeneID; 19301; -.
DR KEGG; mmu:19301; -.
DR CTD; 5827; -.
DR MGI; MGI:107487; Pxmp2.
DR eggNOG; KOG1944; Eukaryota.
DR InParanoid; P42925; -.
DR OrthoDB; 1324608at2759; -.
DR PhylomeDB; P42925; -.
DR Reactome; R-MMU-9603798; Class I peroxisomal membrane protein import.
DR BioGRID-ORCS; 19301; 1 hit in 71 CRISPR screens.
DR PRO; PR:P42925; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; P42925; protein.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0005778; C:peroxisomal membrane; ISO:MGI.
DR GO; GO:0005777; C:peroxisome; ISO:MGI.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR InterPro; IPR007248; Mpv17_PMP22.
DR PANTHER; PTHR11266; PTHR11266; 1.
DR Pfam; PF04117; Mpv17_PMP22; 1.
PE 1: Evidence at protein level;
KW Membrane; Peroxisome; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..194
FT /note="Peroxisomal membrane protein 2"
FT /id="PRO_0000218930"
FT TOPO_DOM 1..30
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..74
FT /note="Peroxisomal"
FT /evidence="ECO:0000255"
FT TRANSMEM 75..95
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 96..113
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..172
FT /note="Peroxisomal"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 58..60
FT /note="KQR -> RK (in Ref. 2 and 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 64..65
FT /note="RL -> QN (in Ref. 2 and 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 194 AA; 22266 MW; 163AE9BDE638B1FC CRC64;
MAPAASRLRV ESELGSLPKR ALAQYLLLLK LYPVLTKAVS SGILSALGNL LAQTIEKKQR
KDSRLLEVSG LLRYLVYGLF VTGPLSHYLY LFMEYSVPPE VPWASVKRLL LDRLFFAPTF
LLLFFFVMNL LEGKNVSVFV AKMRSGFWPA LQMNWRMWTP LQFININYVP LQFRVLFANM
AALFWYAYLA SLGK
