ID   PXMP2_RAT               Reviewed;         194 AA.
AC   Q07066;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Peroxisomal membrane protein 2;
DE   AltName: Full=22 kDa peroxisomal membrane protein;
GN   Name=Pxmp2; Synonyms=Pmp22;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-19; 31-37; 135-139
RP   AND 145-154.
RC   TISSUE=Liver;
RX   PubMed=8422909; DOI=10.1016/0014-5793(93)81167-x;
RA   Kaldi K., Diestelkoetter P., Stenbeck G., Auerbach S., Jaekle U.,
RA   Maegert H.-J., Wieland F.T., Just W.W.;
RT   "Membrane topology of the 22 kDa integral peroxisomal membrane protein.";
RL   FEBS Lett. 315:217-222(1993).
CC   -!- FUNCTION: Seems to be involved in pore-forming activity and may
CC       contribute to the unspecific permeability of the peroxisomal membrane.
CC   -!- SUBUNIT: Interacts with PEX19 and SIVA1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC       {ECO:0000305}.
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DR   EMBL; X70223; CAA49756.1; -; mRNA.
DR   PIR; S28850; S28850.
DR   RefSeq; NP_113775.1; NM_031587.1.
DR   AlphaFoldDB; Q07066; -.
DR   BioGRID; 248168; 1.
DR   STRING; 10116.ENSRNOP00000053518; -.
DR   PaxDb; Q07066; -.
DR   PRIDE; Q07066; -.
DR   GeneID; 29533; -.
DR   KEGG; rno:29533; -.
DR   UCSC; RGD:61812; rat.
DR   CTD; 5827; -.
DR   RGD; 61812; Pxmp2.
DR   eggNOG; KOG1944; Eukaryota.
DR   InParanoid; Q07066; -.
DR   OrthoDB; 581771at2759; -.
DR   PhylomeDB; Q07066; -.
DR   Reactome; R-RNO-9603798; Class I peroxisomal membrane protein import.
DR   PRO; PR:Q07066; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005779; C:integral component of peroxisomal membrane; TAS:RGD.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005778; C:peroxisomal membrane; IDA:UniProtKB.
DR   GO; GO:0005777; C:peroxisome; IDA:UniProtKB.
DR   GO; GO:0032991; C:protein-containing complex; ISO:RGD.
DR   InterPro; IPR007248; Mpv17_PMP22.
DR   PANTHER; PTHR11266; PTHR11266; 1.
DR   Pfam; PF04117; Mpv17_PMP22; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Membrane; Peroxisome; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:8422909"
FT   CHAIN           2..194
FT                   /note="Peroxisomal membrane protein 2"
FT                   /id="PRO_0000218931"
FT   TOPO_DOM        2..30
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        52..74
FT                   /note="Peroxisomal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        96..113
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..134
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        135..172
FT                   /note="Peroxisomal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   194 AA;  22577 MW;  4BEDB2CEBE52EAAC CRC64;
     MAPAASRLRV ESELRSLPKR ALAQYLLFLK FYPVVTKAVS SGILSALGNL LAQMIEKKQK
     KDSRSLEVSG LLRYLVYGLF VTGPLSHYLY LFMEYWVPPE VPWARVKRLL LDRLFFAPTF
     LLLFFFVMNL LEGKNISVFV AKMRSGFWPA LQMNWRMWTP LQFININYVP LQFRVLFANM
     AALFWYAYLA SLGK