PXMP4_MOUSE
ID PXMP4_MOUSE Reviewed; 212 AA.
AC Q9JJW0; Q3U0L9; Q9CQV9;
DT 28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Peroxisomal membrane protein 4;
DE AltName: Full=24 kDa peroxisomal intrinsic membrane protein;
GN Name=Pxmp4; Synonyms=Pmp24;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Van Veldhoven P.P.;
RT "Peroxisomal integral membrane proteins.";
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Embryonic head, Heart, Spleen, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Kidney, Liver, Lung, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Interacts with PEX19. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250}; Multi-pass
CC membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC {ECO:0000305}.
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DR EMBL; AJ271476; CAB71345.1; -; mRNA.
DR EMBL; AK003127; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK019381; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK050647; BAC34361.1; -; mRNA.
DR EMBL; AK156743; BAE33833.1; -; mRNA.
DR EMBL; BC025796; AAH25796.1; -; mRNA.
DR CCDS; CCDS16936.1; -.
DR RefSeq; NP_067509.1; NM_021534.3.
DR AlphaFoldDB; Q9JJW0; -.
DR STRING; 10090.ENSMUSP00000000896; -.
DR GlyGen; Q9JJW0; 1 site.
DR PhosphoSitePlus; Q9JJW0; -.
DR EPD; Q9JJW0; -.
DR jPOST; Q9JJW0; -.
DR MaxQB; Q9JJW0; -.
DR PaxDb; Q9JJW0; -.
DR PeptideAtlas; Q9JJW0; -.
DR PRIDE; Q9JJW0; -.
DR ProteomicsDB; 301955; -.
DR Antibodypedia; 54645; 134 antibodies from 22 providers.
DR DNASU; 59038; -.
DR Ensembl; ENSMUST00000000896; ENSMUSP00000000896; ENSMUSG00000000876.
DR GeneID; 59038; -.
DR KEGG; mmu:59038; -.
DR UCSC; uc008njm.1; mouse.
DR CTD; 11264; -.
DR MGI; MGI:1891701; Pxmp4.
DR VEuPathDB; HostDB:ENSMUSG00000000876; -.
DR eggNOG; ENOG502RXMH; Eukaryota.
DR GeneTree; ENSGT00390000001562; -.
DR HOGENOM; CLU_054132_1_0_1; -.
DR InParanoid; Q9JJW0; -.
DR OMA; DHWDSLR; -.
DR OrthoDB; 1238512at2759; -.
DR PhylomeDB; Q9JJW0; -.
DR TreeFam; TF105313; -.
DR Reactome; R-MMU-9603798; Class I peroxisomal membrane protein import.
DR BioGRID-ORCS; 59038; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Pxmp4; mouse.
DR PRO; PR:Q9JJW0; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q9JJW0; protein.
DR Bgee; ENSMUSG00000000876; Expressed in right kidney and 196 other tissues.
DR ExpressionAtlas; Q9JJW0; baseline and differential.
DR Genevisible; Q9JJW0; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005778; C:peroxisomal membrane; ISO:MGI.
DR GO; GO:0005777; C:peroxisome; ISO:MGI.
DR InterPro; IPR019531; Pmp4.
DR PANTHER; PTHR15460; PTHR15460; 1.
DR PIRSF; PIRSF013674; PXMP4; 1.
PE 1: Evidence at protein level;
KW Glycoprotein; Membrane; Peroxisome; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..212
FT /note="Peroxisomal membrane protein 4"
FT /id="PRO_0000218933"
FT TRANSMEM 97..117
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CARBOHYD 206
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 212 AA; 24196 MW; 4C6FAC8BCB535417 CRC64;
MAAPPQLQAL LQAVNKLLRQ RRYHAALAVI KGFRNGAVYG VKIRAPHALV MTFLFRSGSL
REKLQAILKA TYIHSRNLAC FVFAYKSLHA LQSHVQGETH QMHSFLAAFI GGLLLFGENN
NINSQINMYL TSRVLYALCR LGVEKGYIPA LKWDPFPLHT AVIWGLVLWL FEYHRPTLQP
SLQSSMTYLY EDSNVWHDLS DFLIFNKSHP SK
