ID   PXMP4_RAT               Reviewed;         212 AA.
AC   P59382;
DT   28-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Peroxisomal membrane protein 4;
DE   AltName: Full=24 kDa peroxisomal intrinsic membrane protein;
GN   Name=Pxmp4; Synonyms=Pmp24;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Fischer 344;
RA   Yao R., Wang Y., You M.;
RT   "A new Rattus norvegicus gene is highly homologous to Mus musculus PMP24
RT   protein.";
RL   Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   PROTEIN SEQUENCE OF 2-14, AND CHARACTERIZATION.
RC   TISSUE=Liver;
RX   PubMed=10366717; DOI=10.1016/s0167-4781(99)00061-5;
RA   Reguenga C., Oliveira M.E.M., Gouveia A.M.M., Eckerskorn C., Sa-Miranda C.,
RA   Azevedo J.E.;
RT   "Identification of a 24 kDa intrinsic membrane protein from mammalian
RT   peroxisomes.";
RL   Biochim. Biophys. Acta 1445:337-341(1999).
CC   -!- SUBUNIT: Interacts with PEX19. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Liver.
CC   -!- SIMILARITY: Belongs to the peroxisomal membrane protein PXMP2/4 family.
CC       {ECO:0000305}.
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DR   EMBL; AY151834; AAN72218.1; -; mRNA.
DR   EMBL; BC081699; AAH81699.1; -; mRNA.
DR   RefSeq; NP_757377.1; NM_172223.2.
DR   AlphaFoldDB; P59382; -.
DR   STRING; 10116.ENSRNOP00000022914; -.
DR   GlyGen; P59382; 1 site.
DR   iPTMnet; P59382; -.
DR   PhosphoSitePlus; P59382; -.
DR   PaxDb; P59382; -.
DR   PRIDE; P59382; -.
DR   Ensembl; ENSRNOT00000022914; ENSRNOP00000022914; ENSRNOG00000016975.
DR   GeneID; 282634; -.
DR   KEGG; rno:282634; -.
DR   UCSC; RGD:628782; rat.
DR   CTD; 11264; -.
DR   RGD; 628782; Pxmp4.
DR   eggNOG; ENOG502RXMH; Eukaryota.
DR   GeneTree; ENSGT00390000001562; -.
DR   HOGENOM; CLU_054132_1_0_1; -.
DR   InParanoid; P59382; -.
DR   OMA; DHWDSLR; -.
DR   OrthoDB; 1238512at2759; -.
DR   PhylomeDB; P59382; -.
DR   TreeFam; TF105313; -.
DR   Reactome; R-RNO-9603798; Class I peroxisomal membrane protein import.
DR   PRO; PR:P59382; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Bgee; ENSRNOG00000016975; Expressed in adult mammalian kidney and 18 other tissues.
DR   Genevisible; P59382; RN.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005778; C:peroxisomal membrane; IDA:UniProtKB.
DR   InterPro; IPR019531; Pmp4.
DR   PANTHER; PTHR15460; PTHR15460; 1.
DR   PIRSF; PIRSF013674; PXMP4; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Glycoprotein; Membrane; Peroxisome;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:10366717"
FT   CHAIN           2..212
FT                   /note="Peroxisomal membrane protein 4"
FT                   /id="PRO_0000218934"
FT   TRANSMEM        97..117
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        151..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        206
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   212 AA;  24136 MW;  07D3A5F0A7841A36 CRC64;
     MAAPPQLRAL LQAVNKLLRQ RRYHAALAVI KGFRNGAVYG VKIRAPHALV MTFLFRSGSL
     QEKLQAILKA TYTHSRNLAC FVFTYKSLQA LQSHVQGGTH QMHSFLAAFI GGLLLFGENN
     NINSQINMYL TSRVLFALCR LGVEKGYIPA LKWDPFPLHT AVIWGLVLWL FEYHRPTLQP
     SLQSSMTYLY EDSNVWHDLS DFLIFNKSRP SK