ID   PXP2_SCHPO              Reviewed;         213 AA.
AC   O74758;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Peroxisomal protein 2;
GN   ORFNames=SPBC17D11.03c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: Probably involved in peroxisome formation or maintenance as
CC       well as in amino acid metabolism. {ECO:0000250|UniProtKB:P47148}.
CC   -!- SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000250|UniProtKB:P47148}.
CC       Cytoplasm, cytosol {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}.
CC   -!- DOMAIN: Peroxisomal targeting signal 1 (PTS1) is a tripeptide located
CC       at the C-terminus of more than 95% of all peroxisomal matrix proteins.
CC       The prototypical PTS1 is the terminal tripeptide SKL (serine-lysine-
CC       leucine) but the consensus of PTS1 is defined as [S/A/H/C/E/P/Q/V]
CC       [K/R/H/Q] [L/F]. However, this description of the PTS1 consensus must
CC       probably be expanded beyond the terminal tripeptide.
CC       {ECO:0000250|UniProtKB:P47148}.
CC   -!- SIMILARITY: Belongs to the PXP2 family. {ECO:0000305}.
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DR   EMBL; CU329671; CAA21074.1; -; Genomic_DNA.
DR   PIR; T39714; T39714.
DR   RefSeq; NP_596377.1; NM_001022298.2.
DR   AlphaFoldDB; O74758; -.
DR   SMR; O74758; -.
DR   BioGRID; 276191; 5.
DR   STRING; 4896.SPBC17D11.03c.1; -.
DR   MaxQB; O74758; -.
DR   PaxDb; O74758; -.
DR   PRIDE; O74758; -.
DR   EnsemblFungi; SPBC17D11.03c.1; SPBC17D11.03c.1:pep; SPBC17D11.03c.
DR   GeneID; 2539635; -.
DR   KEGG; spo:SPBC17D11.03c; -.
DR   PomBase; SPBC17D11.03c; -.
DR   VEuPathDB; FungiDB:SPBC17D11.03c; -.
DR   eggNOG; ENOG502RCP9; Eukaryota.
DR   HOGENOM; CLU_065389_3_1_1; -.
DR   InParanoid; O74758; -.
DR   OMA; VGFPRTI; -.
DR   PhylomeDB; O74758; -.
DR   PRO; PR:O74758; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005739; C:mitochondrion; ISS:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0005782; C:peroxisomal matrix; IEA:UniProtKB-SubCell.
DR   GO; GO:0051920; F:peroxiredoxin activity; IEA:InterPro.
DR   GO; GO:0098869; P:cellular oxidant detoxification; ISM:PomBase.
DR   Gene3D; 1.20.1290.10; -; 1.
DR   InterPro; IPR029032; AhpD-like.
DR   InterPro; IPR003779; CMD-like.
DR   Pfam; PF02627; CMD; 1.
DR   SUPFAM; SSF69118; SSF69118; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Peroxisome; Reference proteome.
FT   CHAIN           1..213
FT                   /note="Peroxisomal protein 2"
FT                   /id="PRO_0000317091"
FT   MOTIF           211..213
FT                   /note="Peroxisomal target signal 1 (PTS1)"
FT                   /evidence="ECO:0000250|UniProtKB:P47148"
SQ   SEQUENCE   213 AA;  23489 MW;  6A5FAAB329F7EE58 CRC64;
     MTHNTMLQRF NGLLEPTHLY IVSVVAYSAC NRPDKISGIA KEAMEHVGPS IYPKLREALV
     KSSPLVGFPR TINSLREMTT NIPPPFPDEF ARAADADIDT GKRGKIYFEK TYGKVTQRVL
     RSMQSSSLDL ANIALDYAYG KVLSFNEVVS PLETSLMIIA ALVPQDVNPQ LRGHLKGALN
     HGATKEQVMS ARNIALEISK ECGIQFKGDI ETL