AAEA_ESCF3
ID AAEA_ESCF3 Reviewed; 310 AA.
AC B7LRL6;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=p-hydroxybenzoic acid efflux pump subunit AaeA {ECO:0000255|HAMAP-Rule:MF_01544};
DE Short=pHBA efflux pump protein A {ECO:0000255|HAMAP-Rule:MF_01544};
GN Name=aaeA {ECO:0000255|HAMAP-Rule:MF_01544}; OrderedLocusNames=EFER_3219;
OS Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM
OS 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585054;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35469 / DSM 13698 / BCRC 15582 / CCUG 18766 / IAM 14443 / JCM
RC 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73;
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
CC -!- FUNCTION: Forms an efflux pump with AaeB. {ECO:0000255|HAMAP-
CC Rule:MF_01544}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01544}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01544}.
CC -!- INDUCTION: Positively coregulated with aaeB and aaeX by AaeR.
CC {ECO:0000255|HAMAP-Rule:MF_01544}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000255|HAMAP-Rule:MF_01544}.
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DR EMBL; CU928158; CAQ90712.1; -; Genomic_DNA.
DR RefSeq; WP_000854043.1; NC_011740.1.
DR AlphaFoldDB; B7LRL6; -.
DR SMR; B7LRL6; -.
DR EnsemblBacteria; CAQ90712; CAQ90712; EFER_3219.
DR KEGG; efe:EFER_3219; -.
DR HOGENOM; CLU_018816_15_2_6; -.
DR OMA; EVEPTFN; -.
DR OrthoDB; 757027at2; -.
DR BioCyc; EFER585054:EFER_RS16200-MON; -.
DR Proteomes; UP000000745; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01544; AaeA; 1.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR InterPro; IPR022871; PHBA_efflux_pump_AaeA.
DR InterPro; IPR006143; RND_pump_MFP.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR TIGRFAMs; TIGR01730; RND_mfp; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..310
FT /note="p-hydroxybenzoic acid efflux pump subunit AaeA"
FT /id="PRO_1000146720"
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01544"
SQ SEQUENCE 310 AA; 34624 MW; 42A7DC50A1E60ADA CRC64;
MKTLIRKLTR TAITLVLVIL AFIAIFRAWV YYTESPWTRD ARFSADVVAI APDVAGLITN
VNVHDNQLVK KGQVLFTIDQ PRYQKALAEA EADVAYYSVL AQEKRQEASR RNRLGVQAMS
REEIDQANNV LQTVLHQLAK AQATRDLAKL DLERTVIRAP ADGWVTNLNV YTGEFITRGS
TAVALVKQNT FYVLAYMEET KLEGVRPGYR AEITPLGSNR VLKGTVDSIA AGVTNASSTR
DAKGMATIDS NLEWVRLAQR VPVRIRLDAQ PENLWPAGTT ATVVVTGKDD RDESQDSFFR
KMAHRLREFG
