ID   PXR1_AJECN              Reviewed;         320 AA.
AC   A6R371;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Protein PXR1;
DE   AltName: Full=PinX1-related protein 1;
GN   Name=PXR1; ORFNames=HCAG_04079;
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma;
OC   unclassified Histoplasma.
OX   NCBI_TaxID=2059318;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Involved in rRNA-processing at A0, A1 and A2 sites and
CC       regulates negatively telomerase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PINX1 family. {ECO:0000305}.
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DR   EMBL; CH476658; EDN07569.1; -; Genomic_DNA.
DR   RefSeq; XP_001540239.1; XM_001540189.1.
DR   AlphaFoldDB; A6R371; -.
DR   STRING; 339724.A6R371; -.
DR   EnsemblFungi; EDN07569; EDN07569; HCAG_04079.
DR   GeneID; 5447035; -.
DR   KEGG; aje:HCAG_04079; -.
DR   VEuPathDB; FungiDB:HCAG_04079; -.
DR   HOGENOM; CLU_052839_0_0_1; -.
DR   OMA; WDQSSEA; -.
DR   OrthoDB; 1577610at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR000467; G_patch_dom.
DR   Pfam; PF01585; G-patch; 1.
DR   SMART; SM00443; G_patch; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   CHAIN           1..320
FT                   /note="Protein PXR1"
FT                   /id="PRO_0000324876"
FT   DOMAIN          25..79
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          152..298
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        180..215
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        243..292
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   320 AA;  36092 MW;  42E36D1A24374DEC CRC64;
     MGLAGPRKRT KISHDPNNTA WSRSTSGYGH KIMSAQGWTP GSFLGASNAA HADHFTAGSA
     GHIRVILKDD NLGLGAKLRA EDEPTGLDAF QGLLGRLNGK SDEELEKELK KRHDRQLANF
     VEKRWKTMQF VSGGLLVHEK IQALADVKSA GGEEVQTPQI SHDELKSEKR PKKARKKEKR
     RARGDDTGLD LAEQSPKRKR KDRKENKEKK KSSDDSSYAN QGTPSEDALV DKIQKKRKKR
     KQKDPEPSNT EVHDDSLPPD TRSVSQEEQE SRYSAKNESI RKIREHRPMG RQFTRGRHIQ
     QKKLALMDSK SISEIFMVKC