PXR1_ASHGO
ID PXR1_ASHGO Reviewed; 335 AA.
AC Q751P0;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Protein PXR1;
DE AltName: Full=PinX1-related protein 1;
GN Name=PXR1; OrderedLocusNames=AGL350C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Involved in rRNA-processing at A0, A1 and A2 sites and
CC regulates negatively telomerase. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PINX1 family. {ECO:0000305}.
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DR EMBL; AE016820; AAS54141.1; -; Genomic_DNA.
DR RefSeq; NP_986317.1; NM_211379.1.
DR AlphaFoldDB; Q751P0; -.
DR STRING; 33169.AAS54141; -.
DR EnsemblFungi; AAS54141; AAS54141; AGOS_AGL350C.
DR GeneID; 4622610; -.
DR KEGG; ago:AGOS_AGL350C; -.
DR eggNOG; KOG2809; Eukaryota.
DR HOGENOM; CLU_052839_0_0_1; -.
DR InParanoid; Q751P0; -.
DR OMA; WDQSSEA; -.
DR Proteomes; UP000000591; Chromosome VII.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0090069; P:regulation of ribosome biogenesis; IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR InterPro; IPR000467; G_patch_dom.
DR Pfam; PF01585; G-patch; 1.
DR SMART; SM00443; G_patch; 1.
DR PROSITE; PS50174; G_PATCH; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000305"
FT CHAIN 2..335
FT /note="Protein PXR1"
FT /id="PRO_0000324877"
FT DOMAIN 25..71
FT /note="G-patch"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT REGION 155..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 335 AA; 38534 MW; ECFD2599FE77C1C1 CRC64;
MGLAATKTKQ RFGLDPRNTT WSNDKSRFGH KYLEKLGWEP GKGLGHASHA MSTHIKVTIK
DDTMGLGAKL KKKEKKDEFD SGECAGLDVF QRILGRLNGK EEVIADELEK QRKENIINGK
WGIHFVKGEV LSSTWDADTM QLKSYSYDKK EITADDAEDA KVSGKHRDRK SRAKREKSNN
AALKEKCRDI DRTRKSKRKE KEQEKEKNRE KKHNGKEHKE KEHKEKKDKK DKKEKKEKKE
KKEKKEKKHK EKSNKRLRSS DSIDDPEATK PSKKSKTKAA DSDNVTRDSM LQPRASAASP
PPTISTRLSV RSKWIRQKRA AVMDPKALNE IFMVT
