ID   PXR1_CANAL              Reviewed;         276 AA.
AC   Q5A660; A0A1D8PM36;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Protein PXR1;
DE   AltName: Full=PinX1-related protein 1;
GN   Name=PXR1; OrderedLocusNames=CAALFM_C404520WA;
GN   ORFNames=CaO19.11312, CaO19.3831;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Involved in rRNA-processing at A0, A1 and A2 sites and
CC       regulates negatively telomerase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PINX1 family. {ECO:0000305}.
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DR   EMBL; CP017626; AOW29200.1; -; Genomic_DNA.
DR   RefSeq; XP_717235.1; XM_712142.1.
DR   AlphaFoldDB; Q5A660; -.
DR   STRING; 237561.Q5A660; -.
DR   PRIDE; Q5A660; -.
DR   GeneID; 3641110; -.
DR   KEGG; cal:CAALFM_C404520WA; -.
DR   CGD; CAL0000197682; orf19.11312.
DR   VEuPathDB; FungiDB:C4_04520W_A; -.
DR   eggNOG; KOG2809; Eukaryota.
DR   HOGENOM; CLU_052839_0_0_1; -.
DR   InParanoid; Q5A660; -.
DR   OMA; WDQSSEA; -.
DR   OrthoDB; 1577610at2759; -.
DR   PRO; PR:Q5A660; -.
DR   Proteomes; UP000000559; Chromosome 4.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0090069; P:regulation of ribosome biogenesis; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR000467; G_patch_dom.
DR   Pfam; PF01585; G-patch; 1.
DR   SMART; SM00443; G_patch; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; rRNA processing.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000305"
FT   CHAIN           2..276
FT                   /note="Protein PXR1"
FT                   /id="PRO_0000324884"
FT   DOMAIN          25..71
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          152..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..173
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        174..214
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        215..230
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        231..245
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   276 AA;  31392 MW;  56A7DFF445142E37 CRC64;
     MGLAGTKIKQ RFGNDPRNTN WSNDTSRFGH QYLAKMGWQQ GSGLGLVSHA LTTHVKVSIK
     DDNLGLGAKL HKRKANGDGG LEEEGTAGLD AFQRILGRLN GKENVVNKVL DNVRDDDIIN
     GKWGMRFVKG ETLSSTWDKE SKKLISYKNI EDDGKKSRKR KADESETKED KKTLKKHKKE
     KKDKKEKKEK KKKKEKKDKK DKKDKKNKKD KKDKKDKKDK KDKIRTGSDE TLVSKESSAT
     PPPIATRLSA RSKWIKQKRA SVMDSKALNE IFMITN